{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:39Z","timestamp":1753869339042,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Action \u201cReinforcement of the Research and Innovation Infrastructure\u201d, PROJECT HELLAS-CH","award":["MIS 5002735"],"award-info":[{"award-number":["MIS 5002735"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In\u2010vitro experimental parametric studies of laser ablation using natural sialoliths and artificial stones have been performed toward an efficient laser treatment of sialolithiasis. Surface microstructure and water adsorption become critical for coupling high power pulsed Ho:YAG laser radiation (<jats:italic>\u03bb<\/jats:italic> = 2080\u2009nm, <jats:italic>\u03c4<\/jats:italic> \u223c250\u2009\u03bcsec), inducing ablative interactions and stone fragmentation. Results reveal a generic trend, with single pulse laser energy density threshold for sialolith ablative erosion at \u223c200\u2009J\u2009cm<jats:sup>\u22122<\/jats:sup> (corresponding to intensity \u223c800\u2009kW\u2009cm<jats:sup>\u22122<\/jats:sup>) and fragmentation rates reaching \u223c1\u2009mm\/pulse at \u223c2400\u2009J\u2009cm<jats:sup>\u22122<\/jats:sup>. This process shows no saturation, suggesting that very high energy density irradiation at low pulse repetition rate is an efficient approach. Such operation facilitates rapid cooling and minimal thermal loading of the oral and maxillofacial area, thus causing negligible adverse effects. The method is expected to contribute to the establishment of an easy and optimal therapeutic protocol for sialolithiasis pathology.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000044-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000044","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T03:23:41Z","timestamp":1586575421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sialolithiasis: Application parameters for an optimal laser therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Ioannis","family":"Faklaris","sequence":"first","affiliation":[{"name":"Department of Materials Science University of Patras  Patras Greece"},{"name":"Dentomaxillofacial Radiology Department 251 Hellenic Air Force and VA General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Bouropoulos","sequence":"additional","affiliation":[{"name":"Department of Materials Science University of Patras  Patras Greece"},{"name":"Foundation for Research &amp; Technology\u2010Hellas\/ICE\u2010HT (FORTH\/ICE\u2010HT)  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-0888","authenticated-orcid":false,"given":"Nikolaos A.","family":"Vainos","sequence":"additional","affiliation":[{"name":"Department of Materials Science University of Patras  Patras Greece"},{"name":"National Hellenic Research Foundation \u2013 TPCI, (NHRF\/TPCI)  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,22]]},"reference":[{"volume-title":"Oral & Maxillofacial Pathology","year":"2002","author":"Neville B. W.","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.102515"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80127-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.08.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/crat.201300201"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600080101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05445-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051691"},{"key":"e_1_2_10_10_1","first-page":"322","volume":"18","author":"Geisthoff U. W.","year":"2007","journal-title":"Oper. Tech. Otolayngol. Head Neck Surg."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23272"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13645709809152853"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.951"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)62652-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)25:1<22::AID-LSM4>3.0.CO;2-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032592"},{"key":"e_1_2_10_18_1","first-page":"1683","volume":"87","author":"Ito H.","year":"1994","journal-title":"Pract. Otorhinolaryngol."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20624"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.04.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-018-0674-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2019.01.009"},{"key":"e_1_2_10_23_1","first-page":"5548","volume":"23","author":"Koch M.","year":"2010","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_10_24_1","unstructured":"Laser Technology VII: Applications of Lasers. Proc. SPIE. (Eds: W. L. Wolinski Z. Jankiewicz R. Romaniuk) vol. 5229 SPIE Bellingham2003."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr010379n"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2010.0115"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcrysgrow.2007.01.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/crat.201500143"},{"key":"e_1_2_10_29_1","unstructured":"Laser Growth Process Photon. Dev. (Ed: N. A. Vainos) Woodhead Publ. Cambridge UK 2012."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.35.006304"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3470092"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110108"},{"key":"e_1_2_10_33_1","unstructured":"H. J. C. M. Sterenborg inProc. SPIE(Ed: L. O. Svaasand) SPIE Berlin1991 vol. 1525 p. 170"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-4018(98)00256-9"},{"volume-title":"Electromagnetic Principles of Integrated Optics","year":"1986","author":"Lee D. L.","key":"e_1_2_10_35_1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-011-0746-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR04850H"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.202000044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202000044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.202000044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202000044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:28:58Z","timestamp":1693931338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202000044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/jbio.202000044"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202000044","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"type":"print","value":"1864-063X"},{"type":"electronic","value":"1864-0648"}],"subject":[],"published":{"date-parts":[[2020,4,22]]},"assertion":[{"value":"2020-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202000044"}}