{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:25:24Z","timestamp":1784838324198,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB013723"],"award-info":[{"award-number":["R01EB013723"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB028615"],"award-info":[{"award-number":["R01EB028615"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral\u2010domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM motions of normal middle ears are compared with those of ears with middle ear infections. The capability of noninvasively measuring the rapid motion of the TM is beneficial to understand the complex dynamics of the human TM, and can ultimately lead to improved diagnosis and management of middle ear infections.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000215-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000215","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T18:15:32Z","timestamp":1595355332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vivo<\/i> dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-4049","authenticated-orcid":false,"given":"Jungeun","family":"Won","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Carle Foundation Hospital  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Carle Foundation Hospital  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Youakim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Carle Foundation Hospital  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Sum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Carle Foundation Hospital  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Barkalifa","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Aksamitiene","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"PhotoniCare, Inc.  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