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Our study aims at assessing the HS\u2010diagnostic potential of infrared spectroscopy from saliva, as a biofluid reflecting the body's pathophysiological state. Infrared spectra from 127 patients (57 HS and 70 non\u2010HS) were processed by multivariate methods: principal component analysis coupled with Kruskal\u2013Wallis or Mann\u2013Whitney tests to identify discriminant spectral wavenumbers and linear discriminant analysis to evaluate the performances of HS\u2010diagnostic approach. Infrared features, mainly in the 1300\u2009cm<jats:sup>\u22121<\/jats:sup>\u20101600\u2009cm<jats:sup>\u22121<\/jats:sup> region, were identified as discriminant for HS and prediction models revealed diagnostic performances of about 80%. Tobacco and obesity, two main HS risk factors, do not seem to alter the infrared diagnosis. This pilot study shows the potential of salivary \u201cliquid biopsy\u201d associated to vibrational spectroscopy to develop a personalized medical approach for HS patients' management.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000327-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000327","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T03:27:45Z","timestamp":1606274865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New insights into hidradenitis suppurativa diagnosis <i>via<\/i> salivary infrared biosignatures: A pilot study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-1311","authenticated-orcid":false,"given":"St\u00e9phane","family":"Derruau","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Reims Champagne\u2010Ardenne  BioSpect 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