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Using high frequency ultrasound, we showed that photobiomodulation (PBM) prevents formation and progression of AAA in the angiotensin\u2010II (Ang\u2010II)\u2010infused, apolipoprotein\u2010e\u2010deficient mouse model. In the current study we report that while challenge of porcine aortic Smooth Muscle Cells (SMCs) with Ang\u2010II (1 \u03bcM) resulted in a marked decay in mitochondrial membrane potential (MitMP) vs non\u2010challenged cells, treatment with PBM (continuous diode laser, 780\u2009nm, 6.7 mW\/cm<jats:sup>2<\/jats:sup>, 5 minutes, 2 J\/cm<jats:sup>2<\/jats:sup>) or pre\u2010incubation with estrogen (50\u2009nM, 1 hour) significantly attenuated this deterioration in MitMP. We also report that PBM and estrogen markedly affected porcine aortic SMC contraction and modified mitochondrial dispersion reflecting important influence on SMC function. These studies provide strong evidence of the important underlying role of mitochondria in the preventive effect of PBM on formation and progression of AAA and its reduced incidence and delayed onset in women.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000329-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000329","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T11:53:35Z","timestamp":1599306815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin\u2013<scp>II<\/scp> challenged porcine aortic smooth muscle cells"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-8958","authenticated-orcid":false,"given":"Lilach","family":"Gavish","sequence":"first","affiliation":[{"name":"Institute for Research in Military Medicine (IRMM) of The Faculty of Medicine The Hebrew University of Jerusalem and the Israel Defense Forces Medical Corps  Jerusalem Israel"},{"name":"The Saul and Joyce Brandman Cardiovascular Research Hub of the Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gilon","sequence":"additional","affiliation":[{"name":"Institute for Research in Military Medicine (IRMM) of The Faculty of Medicine The Hebrew University of Jerusalem and the Israel Defense Forces Medical Corps  Jerusalem Israel"},{"name":"The Saul and Joyce Brandman Cardiovascular Research Hub of the Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Department of Cardiology, Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Beeri","sequence":"additional","affiliation":[{"name":"The Saul and Joyce Brandman Cardiovascular Research Hub of the Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Department of Cardiology, Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"The Saul and Joyce Brandman Cardiovascular Research Hub of the Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Nachman","sequence":"additional","affiliation":[{"name":"Institute for Research in Military Medicine (IRMM) of The Faculty of Medicine The Hebrew University of Jerusalem and the Israel Defense Forces Medical Corps  Jerusalem Israel"},{"name":"The Saul and Joyce Brandman Cardiovascular Research Hub of the Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Department of Internal Medicine Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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