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CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000366-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000366","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T02:58:15Z","timestamp":1607569095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-9112","authenticated-orcid":false,"given":"Chong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siavash","family":"Mazdeyasna","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrana","family":"Mohtasebi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E.","family":"Saatman","sequence":"additional","affiliation":[{"name":"Department of Physiology, Spinal Cord and Brain Injury Research Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics, Department of Internal Medicine University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Spinal Cord and Brain Injury Research Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80555-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199412000-00003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0944"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605566"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112066"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsp049"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0437-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15608521"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1542\/peds.72.5.589","volume":"72","author":"Volpe J. 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