{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:06:30Z","timestamp":1790474790553,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune bullous diseases (AIBDs) still represent a considerable a source of morbidity and mortality: early identification of a specific AIBD is often difficult due to overlapping clinical and\/or laboratory features and time\u2010consuming invasive laboratory tests. We aimed to investigate the potential role of a new imaging technology, line\u2010field confocal optical coherence tomography (LC\u2010OCT), in the non\u2010invasive diagnosis of AIBDs. LC\u2010OCT was performed at lesional, perilesional and contralateral healthy sites in 30 patients, before histology and direct immunofluorescence. LC\u2010OCT examination was able to identify the level of split (subcorneal\/suprabasal\/subepidermal\/sublamina densa), to provide detailed images of the bulla roof morphology and content (eg, erythrocytes\/acantholytic cells\/polymorphonucleates). Areas of intra\/subepidermal detachment were also detected also at clinically normal perilesional skin sites. LC\u2010OCT can support physicians, real time and at bed\u2010site, in the differential diagnosis of various AIBDs and their mimickers. Moreover, it can be used for the identification of subclinical lesions and therapy tapering.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000449-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000449","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T18:00:11Z","timestamp":1613325611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Line field confocal optical coherence tomography: An adjunctive tool in the diagnosis of autoimmune bullous diseases"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-4310","authenticated-orcid":false,"given":"Linda","family":"Tognetti","sequence":"first","affiliation":[{"name":"Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-0659","authenticated-orcid":false,"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Guazzo","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Habougit","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Saint\u2010Etienne  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Santi","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendoline","family":"Diet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Berot","sequence":"additional","affiliation":[{"name":"Dermatology Unit University Hospital of St\u2010Etienne  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilliana","family":"Monnier","sequence":"additional","affiliation":[{"name":"Dermatology department AP\u2010HM, Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pianigiani","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Malvehy","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Department of Dermatology University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Dermatology Unit University Hospital of St\u2010Etienne  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02917.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13314"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"e120\u2010e123","volume":"33","author":"De Pace B.","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306074773"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12391"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14267"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20190071"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00048.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14278"},{"key":"e_1_2_10_12_1","first-page":"27","volume-title":"Skin Bioengineering Techniques and Applications in Dermatology and Cosmetology","author":"Welzel J.","year":"1998"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14795"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13492"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2015.10.591"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2016.02.029"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.10.106007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16857"},{"key":"e_1_2_10_19_1","volume":"2020","author":"Tognetti L.","year":"2020","journal-title":"Skin Res. Tech."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1003a53"},{"key":"e_1_2_10_21_1","volume":"5","author":"Cinotti E.","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_546_19"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12882"},{"key":"e_1_2_10_24_1","first-page":"29","volume":"2020","author":"Tognetti L.","year":"2020","journal-title":"Int. J. Dermatol."},{"issue":"12","key":"e_1_2_10_25_1","first-page":"A80\u2010A81","volume":"147","author":"Monnier J.","year":"2020","journal-title":"Ann. Dermatol. V\u00e9n\u00e9r\u00e9ol."},{"key":"e_1_2_10_26_1","author":"Suppa M.","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"e_1_2_10_27_1","first-page":"1077","volume":"16","author":"Beek N.","year":"2018","journal-title":"JDDG"},{"key":"e_1_2_10_28_1","first-page":"1","volume":"00","author":"Ruini C.","year":"2020","journal-title":"Skin Res. Technol."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.020"},{"issue":"3","key":"e_1_2_10_30_1","first-page":"305","volume":"153","author":"Cozzani E.","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"e_1_2_10_31_1","first-page":"868","volume-title":"Harper's Textbook of Pediatric Dermatology","author":"Beek N.","year":"2020"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1531-1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.071"},{"key":"e_1_2_10_35_1","first-page":"S0190\u20109622(19)3","author":"Navarrete\u2010Dechent C.","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00262"},{"issue":"3","key":"e_1_2_10_37_1","first-page":"e90\u2010e92","volume":"46","author":"Ito M.","year":"2019","journal-title":"J. Dermatol."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15767"},{"issue":"9","key":"e_1_2_10_39_1","first-page":"937","volume":"18","author":"Ha L.","year":"2020","journal-title":"J. Dtsch. Dermatol. Ges."}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202000449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.202000449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202000449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:24:15Z","timestamp":1693553055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202000449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/jbio.202000449"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202000449","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"2020-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202000449"}}