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The aim of this study is to evaluate the safety and efficacy of LED\u2010RL to reduce post\u2010operative scarring. Cutaneous Understanding of Red\u2010light Efficacy on Scarring was a randomized, mock\u2010controlled, single\u2010blind, dose\u2010ranging, split\u2010face phase II clinical trial. Starting 1\u2009week post\u2010surgery, patients received LED\u2010RL irradiation and temperature\u2010controlled mock therapy to incision sites at fluences of 160, 320 or 480\u2009J\/cm<jats:sup>2<\/jats:sup>, triweekly for 3\u2009weeks. Efficacy was assessed at 1, 3 and 6\u201312\u2009months. The primary endpoint was difference in scar pliability between LED\u2010RL\u2010treated and control sites. Secondary outcomes included Patient and Observer Scar Assessment Scale, collagen and water concentration, and adverse events. There were no significant differences in scar pliability between treated and control scars. At certain fluences, treated scars showed greater improvements in observer rating and scar pliability, reflected by greater reductions in induration, from baseline to 6\u00a0months compared to control scars. Treatment\u2010site adverse events included blistering (n\u00a0=\u00a02) and swelling (n\u00a0=\u00a01), which were mild and resolved without sequelae. LED\u2010RL phototherapy is safe in the early postoperative period and may reduce scarring.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202100073-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202100073","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T17:15:01Z","timestamp":1617210901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Light emitting diode\u2010red light for reduction of post\u2010surgical scarring: Results from a dose\u2010ranging, split\u2010face, randomized controlled trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Alana","family":"Kurtti","sequence":"first","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School  Piscataway New Jersey USA"},{"name":"Dermatology Service VA New York Harbor Healthcare System  Brooklyn New York 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