{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:59:52Z","timestamp":1788047992119,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A Novel scalable approach using Terahertz (THz) waves together with the electromagnetic field simulation was applied to investigate four rabbits of eight rabbit corneas in vivo. One eye of each rabbits\u2019 corneas was edema induced; the other eye of the corneas served as the control. The simulation revealed the propagation of THz waves at a certain distance along the sub\u2010surface of the cornea. THz spectra have been collected close to the corneal surface by deviating the direct reflection of the THz beam for the edema cornea, the reflected wave intensity for edema corneas is generally larger compared with the control cornea. Upon edema becomes severe at the end of the observation, the reflected wave intensities obtained by detector corresponding to the corneal deep stroma layer approach to the same value for all observed corneas. Good correlation is observed between central corneal thickness measurements and THz wave reflection signal intensities. Our results demonstrated that THz spectroscopy technique could obtain the information from different corneal sublayers.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202100130-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202100130","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:08:15Z","timestamp":1623236895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vivo sensing of rabbit cornea by terahertz technology"],"prefix":"10.1002","volume":"14","author":[{"given":"Lin","family":"Ke","sequence":"first","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*Star)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*Star)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Yang Steve","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*Star)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*Star)  Singapore"},{"name":"Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abdelaziem","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*Star)  Singapore"},{"name":"School of Material Science and Engineering (MSE) Nanyang Technological University (NTU)  Singapore"},{"name":"National Institute of Laser Enhanced Sciences (NILES) Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Material Science and Engineering (MSE) Nanyang Technological University (NTU)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Pei Wen","family":"Teo","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute (SERI)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodhbir S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute (SERI)  Singapore"},{"name":"Singapore National Eye Centre (SNEC)  Singapore"},{"name":"Ophthalmology and Visual Science Academic Clinical Research Program Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute (SERI)  Singapore"},{"name":"Singapore National Eye Centre (SNEC)  Singapore"},{"name":"Ophthalmology and Visual Science Academic Clinical Research Program Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Eye Institute Statistical Report of America 2014 https:\/\/nei.nih.gov(accessed: September 2015)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15080"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.119667"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.26.4.043011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001230"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000150"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)78373-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1965.00970040479008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005758"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14475"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200105000-00011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.07.050"},{"key":"e_1_2_7_14_1","first-page":"2448202","volume":"11","author":"Liu Y. 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