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Bringing this method to the vagus nerve model could leverage this emerging stimulation approach to be tested in broader preclinical applications. Here, we report the capability of the laser nerve stimulation method on the rat vagus nerve bundle with a 1505\u2010nm diode laser operated in continuous\u2010wave mode. Studies of the stimulation threshold and laser\u2010induced acute thermal injury to the nerve bundle were also performed to determine a temperature window for safe, reliable and reproducible laser stimulation of the rat vagus nerve bundle. The results show that laser stimulation of the vagus nerve bundle provides reliable and reproducible nerve stimulation in a rat model. These results also confirm a threshold temperature of &gt;42\u00b0C with acute nerve damage observed above 46\u00b0C. A strong correlation was obtained between the laser time required to raise the nerve temperature above the stimulation threshold and the mean arterial pressure response. Advantages of the method such as non\u2010contact delivery of external stimulus signals at mm scaled distance in air, enhanced spatial selectivity and electrical artefact\u2010free measurements may indicate its potential to counteract the side effects of conventional electrical vagus nerve stimulation<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202100197-gra-0001.png\" xlink:title=\"image\"\/>.<\/jats:p>","DOI":"10.1002\/jbio.202100197","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T14:28:31Z","timestamp":1631802511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vagus nerve bundle stimulation using 1505\u2010nm laser irradiation in an in\u2010vivo rat model"],"prefix":"10.1002","volume":"15","author":[{"given":"Ozan","family":"Yetis","sequence":"first","affiliation":[{"name":"Izmir Biomedicine and Genome Center  Izmir Turkey"},{"name":"Izmir International Biomedicine and Genome Institute Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Center  Izmir Turkey"},{"name":"Department of Electrical and Electronics Engineering, Faculty of Engineering Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensari","family":"Guneli","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Center  Izmir Turkey"},{"name":"Department of Laboratory Animal Science, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Bagriyanik","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Center  Izmir Turkey"},{"name":"Department of Histology and Embryology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-4011","authenticated-orcid":false,"given":"Serhat","family":"Tozburun","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Center  Izmir Turkey"},{"name":"Izmir International Biomedicine and Genome Institute Dokuz Eylul University  Izmir Turkey"},{"name":"Department of Biophysics, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1951.tb01204.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1952.sp004764"},{"key":"e_1_2_10_4_1","first-page":"296","volume":"25","author":"Goerig M.","year":"2000","journal-title":"Reg. 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