{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:50:47Z","timestamp":1791946247267,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901907"],"award-info":[{"award-number":["81901907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172112"],"award-info":[{"award-number":["82172112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20388"],"award-info":[{"award-number":["U20A20388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Moyamoya is a cerebrovascular disease with a high mortality rate. Early detection and mechanistic studies are necessary. Near\u2010infrared spectroscopy (NIRS) was used to study the signals of the cerebral tissue oxygen saturation index (TOI) and the changes in oxygenated and deoxygenated hemoglobin concentrations (HbO and Hb) in 64 patients with moyamoya disease and 64 healthy volunteers. The wavelet transforms (WT) of TOI, HbO and Hb signals, as well as the wavelet phase coherence (WPCO) of these signals from the left and right frontal lobes of the same subject, were calculated. Features were extracted from the spontaneous oscillations of TOI, HbO and Hb in five physiological activity\u2010related frequency segments. Machine learning models based on support vector machine (SVM), random forest (RF) and extreme gradient boosting (XGBoost) have been built to classify the two groups. For 20\u2010min signals, the 10\u2010fold cross\u2010validation accuracies of SVM, RF and XGBoost were 87%, 85% and 85%, respectively. For 5\u2010min signals, the accuracies of the three methods were 88%, 88% and 84%, respectively. The method proposed in this article has potential for detecting and screening moyamoya with high proficiency. Evaluating the cerebral oxygenation with NIRS shows great potential in screening moyamoya diseases.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202100388-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202100388","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T07:09:42Z","timestamp":1643699382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of moyamoya disease based on cerebral oxygen saturation signals using machine learning methods"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-7322","authenticated-orcid":false,"given":"Tianxin","family":"Gao","sequence":"first","affiliation":[{"name":"School of Life Science, Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyue","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Life Science, Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science, Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houdi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Life Science, Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018563"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-0994-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-021-04959-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2018-0026"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-019-01165-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015991"},{"key":"e_1_2_11_8_1","volume":"45","author":"Du L.","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006014"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.06.009"},{"issue":"8","key":"e_1_2_11_11_1","first-page":"453","volume":"12","author":"Sato K.","year":"1996","journal-title":"Childs Nervous System"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00135-1"},{"issue":"7","key":"e_1_2_11_13_1","first-page":"13079","volume":"9","author":"Yu L. Y.","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13293"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13398"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00787"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.643410"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.001383"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00065"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.5.1.011017"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2020.10.004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9827-y"},{"issue":"6","key":"e_1_2_11_23_1","first-page":"3463","volume":"24","author":"He Y.","year":"2014","journal-title":"Biomed. Mater. Eng."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00669"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319875952"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.91.045002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2818300"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2016.2554661"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2873252"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3920"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.07.030"},{"key":"e_1_2_11_32_1","first-page":"81","volume":"67","author":"Yamamoto S.","year":"2020","journal-title":"Neurosurgery"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.043"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1601600407"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","unstructured":"Chen T.;Guestrin C.;Assoc Comp M.InXGBoost: A Scalable Tree Boosting System 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD) San Francisco CA 2016; pp.785\u2013794.","DOI":"10.1145\/2939672.2939785"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)00082-6"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.02.008"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.98.062413"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.037"},{"key":"e_1_2_11_41_1","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J Mach Learn Res"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105322"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.297085"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19848098"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10146"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22445"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28560"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2021.1929214"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04670-4"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-013-9484-z"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab6cb9"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202100388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.202100388","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202100388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T14:06:27Z","timestamp":1692885987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202100388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/jbio.202100388"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202100388","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"2021-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202100388"}}