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Gas in scattering media absorption spectroscopy (GASMAS) is emerging as a potential clinical cutaneous monitoring tool of lung functions in neonates. A challenge in the clinical translation of GASMAS is to obtain sufficiently high signal\u2010to\u2010noise ratios in the measurements, since the light attenuation is high in human tissue. Previous GASMAS studies on piglets have shown higher signal quality with an internal source, as more light propagates through the lung and the loss due to scattering and absorption is less. In this article we simulated light propagation with an intratracheal and a dermal source, and investigated the signal quality and lung volume probed. The results suggest that GASMAS has the potential to measure respiratory volumes; and the sensitivity is higher for an intratracheal source which also enables to probe most of the lung.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202200041-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202200041","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T16:54:17Z","timestamp":1648400057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Numerical investigation of the influence of the source and detector position for optical measurement of lung volume and oxygen content in preterm infants"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-4731","authenticated-orcid":false,"given":"Andrea","family":"Pacheco","sequence":"first","affiliation":[{"name":"Biophotonics@Tyndall, IPIC Tyndall National Institute  Cork Ireland"},{"name":"Department of Physics University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Jayet","sequence":"additional","affiliation":[{"name":"Biophotonics@Tyndall, IPIC Tyndall National Institute  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie Krite","family":"Svanberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Paediatric Anaesthesiology and Intensive Care Medicine, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Dehghani","sequence":"additional","affiliation":[{"name":"School of Computer Science the University of Birmingham  Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Dempsey","sequence":"additional","affiliation":[{"name":"INFANT Centre Cork University Maternity Hospital, University College Cork  Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Andersson\u2010Engels","sequence":"additional","affiliation":[{"name":"Biophotonics@Tyndall, IPIC Tyndall National Institute  Cork Ireland"},{"name":"Department of Physics University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_10_4_1","first-page":"23","volume":"36","author":"Moss T. 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