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In this article, a mathematical model is developed based on Kubelka's theory to determine light transmission in multilayer materials, such as N95 masks. Using this model, the predicted UV transmittance and absorbance of a N95 mask layers were found to be in close agreement with the experimental values. In addition, when the mask was exposed to UV equally from both surfaces, the estimated minimum UV irradiance inside the N95 mask was 14.5% of the incident irradiance, suggesting a significant degree of light penetration. The proposed model provides a simple and practical methodology for the design and use of UV decontamination equipment for FFRs and other multilayer materials.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202200068-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202200068","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T15:07:57Z","timestamp":1656601677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Generalized <scp>Kubelka's<\/scp> theory for light transmission in multilayer materials and its application for <scp>UV<\/scp> light penetration in filtering facepiece respirators"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2680-0036","authenticated-orcid":false,"given":"Ramin","family":"Farnood","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Housyn","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"ZAP Sterilization Solutions  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-8130","authenticated-orcid":false,"given":"John","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  Toronto Ontario Canada"},{"name":"MW Technologies Inc  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Odegaard","sequence":"additional","affiliation":[{"name":"GAP EnviroMicrobial Services Ltd  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"volume-title":"COVID\u201019 Weekly Epidemiological Update. 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