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Researches on PBMT rarely considered the impact of different light structures. In this study, we irradiated shaven rats with both 650\u2009nm, <jats:italic>m<\/jats:italic>\u00a0=\u00a032 vortex beams and ordinary Gaussian beams. The laser treatment was performed at 24\u2010hour intervals for 20\u2009days. The energy density was set to 4.25\u2009J\/cm<jats:sup>2<\/jats:sup>. The results indicated that low\u2010level vortex beam irradiation led to better stimulation of hair growth than the Gaussian beams, which might be related to deeper penetration. The underlying biological mechanisms are discussed in terms of the activation of Wnt\/\u03b2\u2010catenin\/sonic hedgehog pathway. Our results suggest that low\u2010level vortex beam irradiation is advantageous to the treatment of hair loss because it is technically feasible, convenient and effective.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202200103-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202200103","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T13:32:50Z","timestamp":1660051970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhanced hair growth effects through low\u2010level vortex beams radiation: An experimental animal study"],"prefix":"10.1002","volume":"15","author":[{"given":"Ning","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziling","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Micro\/Nano Optoelectronic Devices of Ministry of Education &amp; Hunan Provincial Key Laboratory of Low\u2010Dimensional Structural Physics and Devices, School of Physics and Electronics Hunan University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Micro\/Nano Optoelectronic Devices of Ministry of Education &amp; Hunan Provincial Key Laboratory of Low\u2010Dimensional Structural Physics and Devices, School of Physics and Electronics Hunan University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yancong","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory for Micro\/Nano Optoelectronic Devices of Ministry of Education &amp; Hunan Provincial Key Laboratory of Low\u2010Dimensional Structural Physics and Devices, School of Physics and Electronics Hunan University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen LUBON Technology Co. 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