{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:42:36Z","timestamp":1791250956658,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019470","name":"Lazio Innova","doi-asserted-by":"publisher","award":["A0114\u20102017\u201013715"],"award-info":[{"award-number":["A0114\u20102017\u201013715"]}],"id":[{"id":"10.13039\/100019470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Theranostics is an emerging therapeutic paradigm of personalized medicine; the term refers to the simultaneous integration of therapy and diagnostics. In this work, theranostic\u2010guided corneal cross\u2010linking was performed on 10 human sclero\u2010corneal tissues. The samples were soaked with 0.22% riboflavin formulation and underwent 9\u00a0minutes UV\u2010A irradiance at 10\u00a0mW\/cm<jats:sup>2<\/jats:sup> using theranostic device, which provided both a measure of corneal riboflavin concentration and a <jats:italic>theranostic score<\/jats:italic> estimating treatment efficacy in real time. A three\u2010element viscoelastic model was developed to fit the deformation response of the cornea to air\u2010puff excitation of dynamic tonometry and to calculate the mean corneal stiffness parameter before and after treatment. Significant correlation was found between the <jats:italic>theranostic score<\/jats:italic> and the increase in mean corneal stiffness (R\u00a0=\u00a00.80; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Accuracy and precision of the <jats:italic>theranostic score<\/jats:italic> in predicting the induced corneal tissue stiffening were both 90%. The riboflavin concentration prior to starting the UV\u2010A photo\u2010therapy phase was the most important variable to allow corneal cross\u2010linking to be effective. Theranostic UV\u2010A light mediated imaging and therapy enables the operator to adopt a precise approach for achieving highly predictable biomechanical strengthening on individual corneas.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202200218-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202200218","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T04:23:58Z","timestamp":1662351838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Theranostic\u2010guided corneal cross\u2010linking: Preclinical evidence on a new treatment paradigm for keratoconus"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-967X","authenticated-orcid":false,"given":"Giuseppe","family":"Lombardo","sequence":"first","affiliation":[{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici, Viale F  Messina Italy"},{"name":"Vision Engineering Italy srl  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-1338","authenticated-orcid":false,"given":"Giuseppe Massimo","family":"Bernava","sequence":"additional","affiliation":[{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici, Viale F  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Serrao","sequence":"additional","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-7102","authenticated-orcid":false,"given":"Marco","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Vision Engineering Italy srl  Rome Italy"},{"name":"Studio Italiano di Oftalmologia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.05.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-021-02019-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122626"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/795738"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12025"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.12.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18651"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.01.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2015.11.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7585"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.169813"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01469a022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000076"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3738"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9385"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2018.07.062"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04595-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.16088"},{"key":"e_1_2_10_22_1","first-page":"150","volume":"13","author":"Koprowski R.","year":"2014","journal-title":"J. Geophys. Res. Planets"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681163.2014.959137"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500235"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20191010-03"},{"key":"e_1_2_10_26_1","first-page":"42","volume":"18","author":"Qin X.","year":"2019","journal-title":"J. Geophys. Res. Planets"},{"key":"e_1_2_10_27_1","unstructured":"KoprowskiR.Image Analysis for Ophthalmological Diagnosis in Studies in Computational Intelligence. Springer ISBN: 978\u20133\u2013319\u201029546\u20106 vol. 631 2016."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.5.5.12"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.04.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1321"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2018.1501491"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11043-018-9390-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.07.030"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160512-02"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2017.10.012"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2015.1133831"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.02.032"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121486"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.05.018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00210"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2016.01.040"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000486"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.506969"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4524"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-13975"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202200218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.202200218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202200218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T21:31:48Z","timestamp":1692480708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202200218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jbio.202200218"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202200218","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"assertion":[{"value":"2022-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200218"}}