{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:13:44Z","timestamp":1778638424133,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mueller matrix imaging polarimetry (MMIP) is a promising technique for the characterization of biological tissues, including the classification of microstructures in pathological diagnosis. To expand the parameter space of Mueller matrix parameters, we propose new vector parameters (VPs) according to the Mueller matrix polar decomposition method. We measure invasive bladder cancer (IBC) with extensive necrosis and high\u2010grade ductal carcinoma in situ (DCIS) with MMIP, and the regions of cancer cells and fibrotic stroma are classified with the VPs. Then the proposed and existing VPs are mapped on the Poincar\u00e9 sphere with 3D visualization, and an indicator of spatial feature is defined based on the minimum enclosing sphere to evaluate the classification capability of the VPs. For both IBC and DCIS, the results show that the proposed VPs exhibit evident contrast between the regions of cancer cells and fibrotic stroma. This study broadens the fundamental Mueller matrix parameters and helps to improve the characterization ability of the MMIP technique.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202200255-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202200255","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T06:31:18Z","timestamp":1666161078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polarization clustering of biological structures with Mueller matrix parameters"],"prefix":"10.1002","volume":"16","author":[{"given":"Yongtai","family":"Chen","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering Dalian University of Technology Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-8460","authenticated-orcid":false,"given":"Jinkui","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Dalian University of Technology Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanlu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology Linyi Central Hospital Linyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital &amp; Institute Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Ultrasound Imaging The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital &amp; Institute Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Dalian University of Technology Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benda","family":"Xin","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Dalian University of Technology Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Dalian University of Technology Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02645-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.387747"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.435166"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-020-00435-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.003643"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.37.001061"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201960139"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.427614"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1555-6611\/ab8adb"},{"key":"e_1_2_8_12_1","first-page":"16","volume":"55","author":"Li P.","year":"2022","journal-title":"J. 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