{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:29Z","timestamp":1786977989319,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI20C2088"],"award-info":[{"award-number":["HI20C2088"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated photobiomodulation (PBM) effects in Sonic hedgehog (Shh) signaling as a potential approach to taste preservation and regeneration. Primary taste cell (TC) cultures were treated with Shh antagonist vismodegib and irradiated using a continuous wave type 630\u2009nm light\u2010emitting diode (10\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) array, with single or multiple doses of 30\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    to determine dose inducing significant upregulation effect. Shh, Ptch, Smo, and Gli1 were significantly upregulated at 120\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , used as the minimum dose in vivo. Vismodegib was administered via daily oral gavage for 21\u2009days (30\u2009mg\/kg) to induce Shh inhibition in the tongue of rat animal models resulting in taste bud damage and taste dysfunction. PBM treatment using a 630\u2009nm laser (3\u2009W\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) at a radiant exposure of 120\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    (24\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    \u2009\u00d7\u20095) successfully upregulated the Shh protein expression, regenerated taste buds, and recovered taste function.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300043-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202300043","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T04:26:00Z","timestamp":1689999960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regeneration of taste through sonic hedgehog upregulation by photobiomodulation"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7702-5024","authenticated-orcid":false,"given":"Ha Young","family":"Lee","sequence":"first","affiliation":[{"name":"Interdisciplinary Program for Medical Laser Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-7838","authenticated-orcid":false,"given":"Celine DG.","family":"Abueva","sequence":"additional","affiliation":[{"name":"Dankook Institute of Medicine and Optics Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-5720","authenticated-orcid":false,"given":"Andrew","family":"Padalhin","sequence":"additional","affiliation":[{"name":"Dankook Institute of Medicine and Optics Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-0103","authenticated-orcid":false,"given":"So Young","family":"Park","sequence":"additional","affiliation":[{"name":"Dankook Institute of Medicine and Optics Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9718-5501","authenticated-orcid":false,"given":"Hyun Seok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program for Medical Laser Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-2276","authenticated-orcid":false,"given":"Phil\u2010Sang","family":"Chung","sequence":"additional","affiliation":[{"name":"Dankook Institute of Medicine and Optics Dankook University  Cheonan Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck 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