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A custom single\u2010sided meta\u2010ultrasonic transducer with an outer diameter of 1.8\u2009mm, focal spot diameter of 1.6\u2009mm, central frequency of 930\u2009kHz, and focal length of 0.8\u2009mm was applied to excite the sample. The sample arm of the ARF\u2010OCE system employed a three\u2010dimensional printed holder that allowed for ultrasound excitation and ARF\u2010OCE detection. The phase\u2010resolved algorithm was combined with a Lamb wave model to depth\u2010resolved evaluate corneal biomechanics after keratoconus and cross\u2010linking treatments (CXL). The results showed that, compare to the healthy cornea, the Lamb wave velocity was significantly reduced in the keratoconus, increased in the cornea after CXL, and increased with cross\u2010linked irradiation energy in the cornea. These results indicated the good clinical translation potential of the proposed novel ARF\u2010OCE.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300074-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300074","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T05:44:46Z","timestamp":1682574286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel acoustic radiation force optical coherence elastography based on ultrasmall ultrasound transducer for biomechanics evaluation of in vivo cornea"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-6234","authenticated-orcid":false,"given":"Yirui","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Physics Nanjing University  Nanjing China"},{"name":"School of Testing and Opto\u2010Electric Engineering Nanchang Hangkong University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medicine Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiulin","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Testing and Opto\u2010Electric Engineering Nanchang Hangkong University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas E.","family":"Gomez Alvarez\u2010arenas","sequence":"additional","affiliation":[{"name":"Ultrasonic and Sensors Technologies Department, Information and Physical Technologies Institute Spanish National Research Council  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine Nanchang University  Nanchang 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