{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:53:43Z","timestamp":1790924023842,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["402091\/2021\u20103"],"award-info":[{"award-number":["402091\/2021\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407975\/2018\u20107"],"award-info":[{"award-number":["407975\/2018\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photobiomodulation therapy (PBMt) combined or not with oral hypoglycemic medication has not been investigated in type 2 diabetes (T2DM) patients. All 10 T2DM patients were assessed randomly at 6 different occasions (3 with and 3 without regular oral hypoglycemic medication). Capillary glycemia was assessed after overnight fast (pre\u2010prandial), 1\u2009h postprandially (standardized meal, 338 kcal), and 30\u2009min, 3\u2009h, 6\u2009h, 12\u2009h post\u2010PBMt (830\u2009nm; 25 arrays of LEDs, 80\u2009mW\/array). Three doses (0\u2009J\u2014sham, 100\u2009J, 240\u2009J per site) were applied bilaterally on quadriceps femoris muscles, hamstrings, triceps surae, ventral upper arm and forearm; and randomly combined or not with oral hypoglicemic medication, totaling six different therapies applied for all 10 TDM2 patients (PBMt sham, PBMt 100\u2009J, PBMt 240\u2009J, PBMt sham\u2009+\u2009medication, PBMt 100\u2009J\u2009+\u2009medication, PBMt 240\u2009J\u2009+\u2009medication). Cardiac autonomic control was assessed by heart rate variability (HRV) indices. Without medication, there was reduction in glycemia after all PBMt doses, with 100\u2009J as the best dose that persisted until 12\u2009h and presented lower area under the curve (AUC). With medication, glycemia decreased similarly among doses. No differences between 100\u2009J and sham\u2009+\u2009medication, but AUC was significantly lower after 100\u2009J, suggesting better glycemic control. Low frequency component of HRV increased after sham\u2009+\u2009medication and 100\u2009J, suggesting higher sympathetic activation. PBMt showed time\u2013 and dose\u2013response effect to reduce glycemia in T2DM patients. Effects on HRV were consistent with glycemic control.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300083-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202300083","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T07:25:36Z","timestamp":1683876336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dose and time\u2013response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double\u2010blind, sham\u2010controlled trial"],"prefix":"10.1002","volume":"16","author":[{"given":"Clara Maria Cobra Branco","family":"Scontri","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Federal University of Sao Carlos  Sao Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-982X","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"de Castro Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Physical Education Federal University of the Jequitinhonha and Mucuri Valleys  Diamantina MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Moraes","family":"Damiani","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Centro Universitario do Sagrado Cora\u00e7\u00e3o  Bauru SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-4605","authenticated-orcid":false,"given":"Michael R.","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Laser Research Centre, Faculty of Health Science University of Johannesburg  Doornfontein South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-3047","authenticated-orcid":false,"given":"Antonio Roberto","family":"Zamun\u00e9r","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research in Kinesiology, Department of Kinesiology Universidad Cat\u00f3lica del Maule  Talca Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-8390","authenticated-orcid":false,"given":"Cleber","family":"Ferraresi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Federal University of Sao Carlos  Sao Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.26.2.77"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.12.53"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12372"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1793"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195166"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13038"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4997\/jrcpe.2020.310"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.09.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0242-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00006"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979837"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.53304"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00389"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000311"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3093005"},{"key":"e_1_2_12_20_1","volume-title":"Oral Hypoglycemic Medications","author":"Ganesan K.","year":"2023"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-012-0269-4"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9025"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00612-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002800"},{"key":"e_1_2_12_25_1","first-page":"615","volume":"5","author":"Arzu D.","year":"2006","journal-title":"J. Sports Sci. Med."},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093272"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-1981"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.03.002"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3745"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600175"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.112075"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202760"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109491"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201960140"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2408-2"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600088"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics9070481"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.11-009.Hamblin"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.09-027.Hamblin"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1723-8"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12397"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01741"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.694099"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00517.2009"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2207"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2022.0031"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.959324"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.518449"},{"key":"e_1_2_12_50_1","first-page":"1143","volume":"2007","author":"Porta A.","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2473-1"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1728-3"},{"key":"e_1_2_12_53_1","first-page":"354","volume":"31","author":"Ferraresi C.","year":"2015","journal-title":"Theory Pract."},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111877"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03434-7"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100109"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3934\/biophy.2017.3.337"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002889"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0580-4"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23410"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13039"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.28.1.64"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13865"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01232.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4364"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02929-8"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339907781368995"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4342-z"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1759-9"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.08.026"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22395"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2018.11.015"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.202300083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:17:38Z","timestamp":1790921858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202300083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jbio.202300083"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202300083","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2023-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300083"}}