{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:53:43Z","timestamp":1790924023034,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Androgenetic alopecia (AGA) is the most common type of hair loss caused by dihydrotestosterone (DHT) binding to androgen receptors in dermal papilla cells (DPCs). Photobiomodulation (PBM) is a promising treatment for AGA but suffers from inconsistent outcomes and inconsistent effective light parameters. This study investigated the impact of red light at various irradiances on normal and DHT\u2010treated DPCs. Our results suggested that red light at 8\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    was most effective in promoting DPCs growth. Furthermore, a range of irradiances from 2 to 64\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    modulated key signaling pathways, including Wnt, FGF, and TGF, in normal and DHT\u2010treated DPCs. Interestingly, 8\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    had a greater impact on these pathways in DHT\u2010treated DPCs and altered the Shh pathway, suggesting that the effect of PBM varies with the cellular environment. This study highlights specific factors that influence PBM effectiveness and provides insight into the need for personalized PBM treatment approaches.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300087-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202300087","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T15:28:10Z","timestamp":1688743690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of photobiomodulation at various irradiances on normal and dihydrotestosterone\u2010treated human hair dermal papilla cells in vitro"],"prefix":"10.1002","volume":"16","author":[{"given":"Miao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Light Source and Illuminating Engineering Fudan University  Shanghai China"},{"name":"Zhongshan Fudan Joint Innovation Center  Zhongshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhongshan Fudan Joint Innovation Center  Zhongshan Guangdong China"},{"name":"Institute of Future Lighting, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangfei","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhongshan Fudan Joint Innovation Center  Zhongshan Guangdong China"},{"name":"Institute of Future Lighting, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Zhongshan Fudan Joint Innovation Center  Zhongshan Guangdong China"},{"name":"Institute of Future Lighting, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Ding","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Organ Repair, School of Medicine Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Surgery, Shanghai Skin Disease Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6057-4960","authenticated-orcid":false,"given":"Muqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Light Source and Illuminating Engineering Fudan University  Shanghai China"},{"name":"Zhongshan Fudan Joint Innovation Center  Zhongshan Guangdong China"},{"name":"Institute of Future Lighting, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00372-6"},{"key":"e_1_2_8_3_1","first-page":"621","volume":"9","author":"Mester E.","year":"1968","journal-title":"Radiobiol. 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