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However, there is a lack of assessment methods for endometrium in vivo. In this research, we intend to develop quantitative imaging markers with optical coherence tomography (OCT)\/ultrasound (US) integrated imaging system through intrauterine endoscopic imaging. OCT\/US integrated imaging system was established as our previous research reported. The endometrial injury model was established and after treatment, OCT\/US integrated imaging and uterus biopsy was performed to evaluate the endometrial thickness, number of superficial fold, and intrauterine area. According to the results, three quantitative indexes acquired from OCT\/US image and HE staining have the same trend and have a strong relationship with the severity of the endometrial injury. Accordingly, we developed three imaging markers for quantitative analysis of endometrial injury in vivo, which provided a precise mode for endometrium evaluation in clinical practice.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300113-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300113","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T08:25:45Z","timestamp":1690014345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imaging biomarker for quantitative analysis of endometrial injury based on optical coherence tomography\/ultrasound integrated imaging mode"],"prefix":"10.1002","volume":"16","author":[{"given":"Meng","family":"Du","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School University of South China  Hengyang Hunan 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