{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T22:13:10Z","timestamp":1783289590742,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to observe the fluorescence characteristics of acne inflammatory skin lesions in 5\u2010aminolevulinic acid\u2010based photodynamic diagnosis (ALA\u2010PDD), and discuss the viability of using ALA\u2010PDD to evaluate acne inflammatory skin lesions and explore the advantages of predicting subclinical skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The OBSERV facial skin detector collected photographs of 20 patients before and after optical intra\u2010tissue fiber irradiation photodynamic therapy (OFI\u2010ALA\u2010PDT) in both ALA\u2010PDD and white light patterns. The patients were treated once a week for four consecutive weeks in order to analyze the correlation between the two patterns in recognizing inflammatory skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before and after treatment, there was no significant difference between the two patterns for recognizing acne inflammatory skin lesions (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Both patterns demonstrated a strong correlation (<jats:italic>r<\/jats:italic>\u2009&gt;\u20090.90) for the recognition of various types of inflammatory skin lesions at different treatment stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALA\u2010PDD is a feasible method for evaluating acne inflammatory lesions, guiding treatment and judging efficacy. It has advantages in predicting subclinical skin lesions and deserves further study.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300160-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p><\/jats:sec>","DOI":"10.1002\/jbio.202300160","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:41:47Z","timestamp":1693363307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A preliminary study on the evaluation of photodynamic diagnosis for acne inflammatory skin lesions"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-8780","authenticated-orcid":false,"given":"Chunlan","family":"Xu","sequence":"first","affiliation":[{"name":"Chengdu University  Chengdu China"},{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Deyang People's Hospital  Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-9665","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-5637","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"142","volume":"2","author":"Xiaojuan L.","year":"2017","journal-title":"J Clin Dermatol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.4.417"},{"key":"e_1_2_9_4_1","first-page":"245","volume":"1","author":"Adeolu A.","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0312-y"},{"key":"e_1_2_9_6_1","first-page":"40","volume":"9","author":"Agnew T.","year":"2016","journal-title":"J Clin Aesth Dermatol"},{"key":"e_1_2_9_7_1","first-page":"100","volume":"25","author":"Becker M.","year":"2016","journal-title":"Clin Dermatol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12865"},{"key":"e_1_2_9_9_1","first-page":"601","volume":"10","author":"Jiang Wencai X.","year":"2019","journal-title":"J Clin Dermatol"},{"key":"e_1_2_9_10_1","first-page":"922","volume":"51","author":"Cheng C.","year":"2018","journal-title":"Chin J Dermatol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12345"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175543"},{"key":"e_1_2_9_13_1","first-page":"65","volume":"48","author":"Ju Q.","year":"2019","journal-title":"J Clin Dermatol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17851"},{"key":"e_1_2_9_15_1","volume":"50","author":"He G.","year":"2020","journal-title":"China Surfact Deterg Cosmet"},{"key":"e_1_2_9_16_1","first-page":"119","volume":"2","author":"Caihong S.","year":"2015","journal-title":"Chin J Dermatol"},{"key":"e_1_2_9_17_1","volume":"7","author":"Liu Y. 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