{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:33:02Z","timestamp":1792153982469,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["CDA 202D800042"],"award-info":[{"award-number":["CDA 202D800042"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Breast cancer diagnosis is crucial for timely treatment and improved outcomes. This paper proposes a novel approach for rapid breast cancer diagnosis using optical fiber probe\u2010based attenuated total reflectance Fourier transform infrared (ATR\u2010FTIR) spectroscopy from 750 to 4000\u2009cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The technique enables direct analysis of tissue samples, eliminating the need for microtome sectioning and staining, thus saving time and resources. By capturing molecular fingerprint information, various machine\u2010learning models were used to analyze the spectroscopic data to classify cancerous and non\u2010cancerous tissues accurately. Comparing deparaffinized and paraffinized samples reveals the impact of sample preparation and experimental methods. The study demonstrates a strong correlation between the cancerous nature of a sample and its ATR\u2010FTIR spectrum, suggesting its potential for breast cancer diagnosis (sensitivity of 74.2% and specificity of 78.3%). The proposed approach holds promise for integration into clinical operations, providing a rapid method for preliminary breast cancer diagnosis.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300199-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202300199","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:54:03Z","timestamp":1690419243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fiber optic probe\u2010based\n                    <scp>ATR\u2010FTIR<\/scp>\n                    spectroscopy for rapid breast cancer detection: A pilot study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-4856","authenticated-orcid":false,"given":"Shuyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science, Technology and Research (A*STAR)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Peng Hwee","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Olivo","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science, Technology and Research (A*STAR)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Breast Cancer","author":"Alkabban F. M.","year":"2023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13050723"},{"key":"e_1_2_8_4_1","article-title":"Screening for Breast Cancer: What You Need to Know","author":"Farrell K.","year":"2020","journal-title":"\u00a0J. Missouri State Med. Assoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v8n3p72"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/nmj.NMJ_173_20"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-849883-5.00005-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6623077"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/9781119962328.ch3","volume-title":"Infrared and Raman Spectroscopy in Forensic Science","author":"Chalmers J. M.","year":"2012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119962328.ch2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233626"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2016.02.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.753791"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-019-02332-w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/213890"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201300149"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.2084"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-010-9326-y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i9.1897"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262489"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0an00543f"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120857"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.04.039"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1018(200003\/04)24:2<101::AID-FAM729>3.0.CO;2-2"},{"key":"e_1_2_8_25_1","unstructured":"P. H. C.Eilers H. F. M.Boelens.Baseline correction with asymmetric least squares smoothing. Leiden University Medical Centre Report.2005."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2015.0202"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2018.05.070"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2020.1843471"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.37595"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2005.10.010"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec173d"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T20:08:36Z","timestamp":1699906116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202300199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jbio.202300199"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202300199","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]},"assertion":[{"value":"2023-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300199"}}