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The image\u2010guided laparoscopic surgical tool (IGLaST) integrated with optical coherence tomography (OCT) has potential for in vivo blood vessel imaging; however, distinguishing vessels from surrounding tissue remains a challenge. In this study, we propose utilizing an inter\u2010A\u2010line intensity differentiation\u2010based OCT angiography (OCTA) to improve visualization of blood vessels. By evaluating a tissue phantom with varying flow speeds, we optimized the system's blood flow imaging capabilities in terms of minimum detectable flow and contrast\u2010to\u2010noise ratio. In vivo experiments on rat and porcine models, successfully visualized previously unidentified blood vessels and concealed blood flows beneath the 1\u2009mm depth peritoneum. Qualitative comparison of various OCTA algorithms indicated that the intensity differentiation\u2010based algorithm performed best for our application. We believe that implementing IGLaST with OCTA can enhance surgical outcomes and reduce procedure time in laparoscopic surgeries.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300221-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300221","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:18:43Z","timestamp":1694078323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Imaging peritoneal blood vessels through optical coherence tomography angiography for laparoscopic surgery"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-1560","authenticated-orcid":false,"given":"Minsuk","family":"Lee","sequence":"first","affiliation":[{"name":"Medical Device Development Center, Osong Medical Innovation Foundation  Cheongju Chungbuk Korea"},{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonjin","family":"Bang","sequence":"additional","affiliation":[{"name":"Medical Device Development Center, Osong Medical Innovation Foundation  Cheongju Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eungjang","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Device Development Center, Osong Medical Innovation Foundation  Cheongju Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Foregut Surgery Anam Hospital, Korea University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Anam Hospital, Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-3135","authenticated-orcid":false,"given":"Hongki","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang\u2010yuhl","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungrag","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Device Development Center, Osong Medical Innovation Foundation  Cheongju Chungbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Mastery of Endoscopic and Laparoscopic Surgery","author":"Soper N. 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