{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:54:51Z","timestamp":1785840891215,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107\u20102112\u2010M\u2010002\u2010023\u2010MY3"],"award-info":[{"award-number":["MOST 107\u20102112\u2010M\u2010002\u2010023\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the in vitro rate of fluorescent advanced glycation end products (fAGEs) formation with multiphoton microscopy in different porcine tissues (aorta, cornea, kidney, dermis, and tendon). These tissues were treated with <jats:sc>d<\/jats:sc>\u2010glucose, <jats:sc>d<\/jats:sc>\u2010galactose, and <jats:sc>d<\/jats:sc>\u2010fructose, three primary monosaccharides found in human diets. We found that the use of <jats:sc>d<\/jats:sc>\u2010fructose resulted in the highest glycation rate, followed by <jats:sc>d<\/jats:sc>\u2010galactose and then <jats:sc>d<\/jats:sc>\u2010glucose. Moreover, compared to non\u2010collagen tissue constituents such as elastic fibers and cells, the rate of tissue glycation was consistently higher in collagen, suggesting that collagen is a more sensitive target for fAGE formation. However, we also found that collagen in different tissues exhibits different rates of fAGE formation, with slower rates observed in tightly packed tissues such as cornea and tendon. Our study suggests that for fAGE to be developed into a long\u2010term glycemic biomarker, loosely organized collagen tissues located in the proximity of vasculature may be the best targets.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300261-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300261","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T04:42:08Z","timestamp":1694148128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-4133","authenticated-orcid":false,"given":"Chih\u2010Ju","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Physics National Taiwan University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-2895","authenticated-orcid":false,"given":"Sohidul","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Physics National Taiwan University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physics National Taiwan University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon\u2010Woong","family":"Kang","sequence":"additional","affiliation":[{"name":"Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T. C.","family":"So","sequence":"additional","affiliation":[{"name":"Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology  Cambridge Massachusetts USA"},{"name":"Department of Mechanical Engineering Massachusetts Institute of Technology  Cambridge Massachusetts USA"},{"name":"Department of Biological Engineering Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-2965","authenticated-orcid":false,"given":"Chen Yuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Physics National Taiwan University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.3.381"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v2.i6.77"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00022-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00138-3"},{"key":"e_1_2_9_8_1","first-page":"21","volume":"21","author":"Poznyak A.","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000018826.59648.07"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.621854"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051591"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.5.489"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00697-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.03.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v4.i4.90"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399052952631"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.11.3103"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.4.405"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.03.018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2121247"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00050-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50084"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.11.3274"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.08.022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1171"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2006.9.274"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1fo10034c"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060739"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.870"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00029"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1676-24442013000200004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3818196"},{"key":"e_1_2_9_34_1","first-page":"403","volume":"314","author":"Monnier V. M.","year":"1986","journal-title":"J. Med."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.000509"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1451-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296813516955"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02420311"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2014.10.02.106"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302731"},{"key":"e_1_2_9_42_1","first-page":"277","volume-title":"In Vivo NADH Fluorescence","author":"Ince C.","year":"1992"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23597"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja070026r"},{"key":"e_1_2_9_45_1","first-page":"1","volume-title":"Optical and structural properties of biological tissues under simulated diabetes mellitus","author":"Tuchina D. K. E. A.","year":"2022"},{"key":"e_1_2_9_46_1","first-page":"517","volume-title":"Diabetes mellitus\u2010induced alterations of tissue optical properties, optical clearing efficiency, and molecular diffusivity","author":"Tuchina D. K.","year":"2022"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.27.8.087001"},{"key":"e_1_2_9_48_1","first-page":"14","volume":"14","author":"Lin C. J.","year":"2021","journal-title":"J. Biophotonics"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297919140086"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.18287\/JBPE18.04.020201"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.18287\/JBPE17.03.020302"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.003149"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.12.012"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.000218"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.874536"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.12192669"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T02:10:41Z","timestamp":1705975841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202300261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jbio.202300261"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202300261","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]},"assertion":[{"value":"2023-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300261"}}