{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:02:20Z","timestamp":1783364540801,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The erbium\u2010doped yttrium aluminum garnet (Er: YAG) laser has been successfully applied in caries removal; however, little is known about proper parameters of Er: YAG laser on different conditions of caries removal, especially the influence of Er: YAG irradiation on human dental pulp cells (hDPCs). Here, we tested the effects of Er: YAG laser at different output energy levels (100, 200, 300, 400, and 500\u2009mJ) on biobehaviors of hDPCs. To simulate clinical deep caries conditions, hDPCs were cultured on the pulpal side of 500\u2010\u03bcm\u2010thick dentin disks in an in vitro pulp chamber model. Temperature change, structural change, and ablation depth of dentin disk were also recorded. The findings suggested that the biological behaviors of hDPCs are strongly correlated with the energy output of the Er: YAG laser. Er: YAG laser irradiation at 100\u2009mJ may be proper and safe for deep caries removal since it would not cause any adverse effect on hDPCs biobehaviors.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300332-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300332","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:53:48Z","timestamp":1701536028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In vitro effect of <scp>Er<\/scp>: <scp>YAG<\/scp> laser irradiation in caries cavity preparation on biobehaviors of adjacent human dental pulp cells in the pulp chamber"],"prefix":"10.1002","volume":"17","author":[{"given":"Shaofeng","family":"Wang","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-5041","authenticated-orcid":false,"given":"Yijun","family":"Li","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Stomatological Hospital of Xiamen Medical College &amp; Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Stomatology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211056247"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2582-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2644-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345980770060501"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1533"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0854-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1086-3"},{"key":"e_1_2_9_9_1","first-page":"8","volume":"51","author":"Zhang Y.","year":"2020","journal-title":"Quintessence Int."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601812010443"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03082-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03615-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082429"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.782095"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111742"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700157"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.11.51"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.08.014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2022.06.025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02161-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1988.tb00968.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.05.023"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1000-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2703"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2007.tb00522.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13424"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.01.026"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbo.2016.12.007"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.7.626"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90015-0"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3132"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4699"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr010379n"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1179\/175889610X12730566149146"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234138","volume":"15","author":"Liao Y.","year":"2020","journal-title":"PLoS One"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(93)90006-A"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.4.667"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03849"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.09.027"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061724"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.5984\/jjpnsoclaserdent.27.84"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.04.012"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3214"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.11-009.Hamblin"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T02:31:07Z","timestamp":1711333867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202300332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jbio.202300332"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202300332","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300332"}}