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The rate of reduction of light scattering coefficient, obtained through an averaged A\u2010scan of the OCT image in the region of dermis within the depths from 350 to 700\u2009\u03bcm, were determined to evaluate the efficiency of optical clearing (EOC). The correlations between the EOC and the energy of intermolecular interaction of OCAs with a fragment of collagen peptide have been established as a result of molecular modeling by quantum chemistry methods HF\/STO3G\/DFT\/B3LYP\/6\u2014311G(d) of a number of OCAs (glycerol, iohexol, sucrose, ribose, fructose, glucose) with mimetic peptide of collagen (GPH)<jats:sub>3<\/jats:sub>.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300354-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300354","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T13:19:35Z","timestamp":1701263975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optical clearing of human skin: Molecular modeling and in vivo OCT study"],"prefix":"10.1002","volume":"17","author":[{"given":"K. 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