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However, studies on nicotinamide (NAm) supplementation in humans indicate that NAm has no protective effect. Sterile alpha and toll\/interleukin receptor motif\u2010containing protein 1 (SARM1) regulates several cell responses to axonal damage and has been implicated in promoting neuronal degeneration. SARM1 inhibition seems to result in protection from neuronal degeneration while hydrogen peroxide has been implicated in oxidative stress and axonal degeneration. The effects of laser\u2010induced axonal damage in wild\u2010type and HD dorsal root ganglion cells treated with NAm, hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), and SARM1 inhibitor DSRM\u20103716 were investigated and the cell body width, axon width, axonal strength, and axon shrinkage post laser\u2010induced injury were measured.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300370-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300370","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:34:42Z","timestamp":1704695682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impacts of <scp>H<sub>2<\/sub>O<sub>2<\/sub><\/scp>, <scp>SARM1<\/scp> inhibition, and high <scp>NAm<\/scp> concentrations on Huntington's disease laser\u2010induced 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