{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:46Z","timestamp":1753869346276,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021YFS0089","2022YFS0607(\u2010B5)"],"award-info":[{"award-number":["2021YFS0089","2022YFS0607(\u2010B5)"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noninvasive and real\u2010time optical detection of cardiac hemodynamics dysfunction during myocardial ischemia remains challenging. In this study, we developed a near\u2010infrared spectroscopy device to monitor rats' myocardial hemodynamics. The well\u2010designed system can accurately reflect the hemodynamics changes by the classic upper limb ischemia test. Systemic hypoxia by disconnecting to the ventilator and cardiac ischemia by coronary artery slipknot ligation was conducted to monitor myocardial hemodynamics. When systemic hypoxia occurred, \u0394HbR and \u0394tHb increased significantly, whereas \u0394HbO decreased rapidly. When coronary blood flow was obstructed by slipknots, cardiothoracic \u0394HbO immediately begins to decline, while \u0394HbR also significantly increases. Simultaneously, SpO<jats:sub>2<\/jats:sub>did not show any obvious changes during myocardial ischemia, while SpO<jats:sub>2<\/jats:sub>decreased significantly during systemic hypoxia. These results demonstrated that cardiothoracic hemodynamics stemmed from myocardial ischemia. This pilot study demonstrated the practicality of noninvasive, low\u2010cost optical monitoring for cardiac oxygenation dysfunction in rats.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300474-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300474","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T06:04:15Z","timestamp":1719554655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive cardiac hemodynamics monitoring of acute myocardial ischemia in rats using near\u2010infrared spectroscopy: A pilot study"],"prefix":"10.1002","volume":"17","author":[{"given":"Sifan","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Yue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"},{"name":"Department of Cardiology The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-0907","authenticated-orcid":false,"given":"Weichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education &amp; Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/3463654"},{"key":"e_1_2_8_5_1","first-page":"493","volume":"30","author":"Tang L.","year":"2014","journal-title":"Acta Cardiol. Sin."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-2-25"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/73\/7\/076701"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.929199"},{"key":"e_1_2_8_9_1","volume":"1","author":"Yu Y.","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800240"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.784821"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120153"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101661"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278276"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69589-6_6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"D.Contini L.Spinelli A.Torricelli A.Pifferi R.Cubeddu L.Ascari L.Pot\u00ed M. G.Trivella A.L'Abbate Biomedical Optics and 3\u2010D Imaging (Miami Florida United States)2010 p. BTuD98.","DOI":"10.1364\/BIOMED.2010.BTuD98"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000604"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.07.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100031"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-020-00610-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201900148"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2019.2944351"},{"key":"e_1_2_8_23_1","volume":"23","author":"Gary C. S.","year":"2023","journal-title":"J. Hand Surg. Am."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12599"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.03.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05286"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microrel.2018.06.017"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.27.7.077001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-012-9348-y"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202300474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T23:18:53Z","timestamp":1732317533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202300474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jbio.202300474"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202300474","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"type":"print","value":"1864-063X"},{"type":"electronic","value":"1864-0648"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300474"}}