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This study presents a non\u2010contact and non\u2010invasive wave\u2010based optical coherence elastography system that utilizes air\u2010pulse stimulation to create a two\u2010dimensional map of corneal elasticity. Homogeneous and dual concentration phantoms were measured with the sampling of 25\u2009\u00d7\u200925 points over a 6.6\u2009\u00d7\u20096.6\u2009mm<jats:sup>2<\/jats:sup> area, to verify the measurement capability for elastic mapping and the spatial resolution (0.91\u2009mm). The velocity of elastic waves distribution of porcine corneas before and after corneal crosslinking surgery were further mapped, showing a significant change in biomechanics in crosslinked region. This system features non\u2010invasiveness and high resolution, holding great potential for application in ophthalmic clinics.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300534-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300534","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:24:10Z","timestamp":1709857450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spatial mapping of corneal biomechanical properties using wave\u2010based optical coherence elastography"],"prefix":"10.1002","volume":"17","author":[{"given":"Qingying","family":"Wang","sequence":"first","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dongguan Tungwah Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Shen","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiao","family":"Shen","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University  Wenzhou China"},{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexi","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-070909-105243"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12345"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.914543"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"e_1_2_9_6_1","volume":"156","author":"Smadja D.","year":"2013","journal-title":"J. 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