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The research findings demonstrate that the combination of novel cationic photosensitizer\u2010mediated PACT and an antibiotic exhibits significant therapeutic efficacy in treating deep ulcers in a rat model of DFUs. Moreover, the PACT\u2009+\u2009Antibiotic group displays enhanced angiogenesis, improved tissue maturation, and superior wound healing effect. Micro\u2010computed tomography examination showed that the periosteal reaction was most obvious in the PACT\u2009+\u2009Antibiotic group. The cortical bone volume ratio (BV\/TV), the bone mineral density, and trabecular thickness were significantly higher in the PACT\u2009+\u2009Antibiotic group than in the model group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The combination of PACT and antibiotic plays a sensitizing therapeutic role, which provides a new idea for the clinical treatment of DFUs.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202300568-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202300568","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T08:35:36Z","timestamp":1713861336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the efficacy of photodynamic antimicrobial chemotherapy on diabetic foot ulcers in rats"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-6281","authenticated-orcid":false,"given":"Zhanjuan","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwen","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cangzhou Hospital of Integrated TCM\u2010WM Hebei  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Foreign Languages, Tianjin University of Commerce  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiman","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine, Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyan","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhong","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine, Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Hebei University  Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S067"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002529"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2019.02.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2012_2085"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-11-19-5161"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56080380"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2017.10.010"},{"key":"e_1_2_11_11_1","first-page":"140","volume":"1","author":"Liu Y.","year":"2015","journal-title":"J. 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