{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:00:30Z","timestamp":1783720830211,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100019470","name":"Lazio Innova","doi-asserted-by":"publisher","award":["A0613\u20102023\u2010077528"],"award-info":[{"award-number":["A0613\u20102023\u2010077528"]}],"id":[{"id":"10.13039\/100019470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seven human donor eye globes underwent corneal cross\u2010linking using theranostic UV\u2010A device with accessory corneal iontophoresis system for patterned delivery of a 0.22% riboflavin solution. Theranostic\u2010guided UV\u2010A light illumination assessed riboflavin distribution and treated corneas at 10\u2009mW\/cm<jats:sup>2<\/jats:sup> for 9\u2009min with a 5.0\u2010mm beam size. Corneal topography maps were taken at baseline and 2\u2010h post\u2010treatment. Analysis utilized corneal topography elevation data, with results showing controlled riboflavin delivery led to a consistent gradient, with 40% higher levels centrally (248\u2009\u00b1\u200979\u2009\u03bcg\/cm<jats:sup>3<\/jats:sup>) than peripherally (180\u2009\u00b1\u200972\u2009\u03bcg\/cm<jats:sup>3<\/jats:sup> at \u00b12.5\u2009mm from the center). Theranostic\u2010guided UV\u2010A light irradiation resulted in significant changes in corneal topography, with a decrease in best\u2010fit sphere value (\u22120.7\u2009\u00b1\u20090.2 D; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and consistent downward shift in corneal elevation map (\u221211.7\u2009\u00b1\u20093.7\u2009\u03bcm). The coefficient of variation was 2.5%, indicating high procedure performance in achieving significant and reliable corneal flattening.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202400068-gra-0005.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202400068","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:44:21Z","timestamp":1714693461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spatial targeted delivery of riboflavin with a controlled corneal iontophoresis delivery system in theranostic\u2010guided <scp>UV\u2010A<\/scp> light photo\u2010therapy"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-7102","authenticated-orcid":false,"given":"Marco","family":"Lombardo","sequence":"first","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"Vision Engineering Italy srl  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-6462","authenticated-orcid":false,"given":"Sebastiano","family":"Serrao","sequence":"additional","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"Vision Engineering Italy srl  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-1338","authenticated-orcid":false,"given":"Giuseppe Massimo","family":"Bernava","sequence":"additional","affiliation":[{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-967X","authenticated-orcid":false,"given":"Giuseppe","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0410"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.01.026"},{"key":"e_1_2_10_4_1","volume":"3","author":"Ng S. 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