{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:01:12Z","timestamp":1773014472325,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Here we introduce a Raman spectroscopy approach combining multi\u2010spectral imaging and a new fluorescence background subtraction technique to image individual Raman peaks in less than 5\u2009seconds over a square field\u2010of\u2010view of 1\u2010centimeter sides with 350 micrometers resolution. First, human data is presented supporting the feasibility of achieving cancer detection with high sensitivity and specificity \u2013 in brain, breast, lung, and ovarian\/endometrium tissue \u2013 using no more than three biochemically interpretable biomarkers associated with the inelastic scattering signal from specific Raman peaks. Second, a proof\u2010of\u2010principle study in biological tissue is presented demonstrating the feasibility of detecting a single Raman band \u2013 here the CH\n                    <jats:sub>2<\/jats:sub>\n                    \/CH\n                    <jats:sub>3<\/jats:sub>\n                    deformation bands from proteins and lipids \u2013 using a conventional multi\u2010spectral imaging system in combination with the new background removal method. This study paves the way for the development of a new Raman imaging technique that is rapid, label\u2010free, and wide field.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202400087-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202400087","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:14:58Z","timestamp":1720062898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward noncontact macroscopic imaging of multiple cancers using multi\u2010spectral inelastic scattering detection"],"prefix":"10.1002","volume":"17","author":[{"given":"Sandryne","family":"David","sequence":"first","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassim","family":"Ksantini","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rick","family":"Dallaire","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ember","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Daoust","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Sheehy","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costas G.","family":"Hadjipanayis","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital  New York New York USA"},{"name":"University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Petrecca","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5543-666X","authenticated-orcid":false,"given":"Brian C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center\u2010University Health Network\/University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-4952","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Leblond","sequence":"additional","affiliation":[{"name":"Department of Engineering Physics Polytechnique Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"},{"name":"Institut du Cancer de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa2384"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0213"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0668"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500204"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA06831G"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160714554"},{"key":"e_1_2_3_8_1","first-page":"1","volume":"29","author":"David S.","year":"2023","journal-title":"J. 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