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Functional near\u2010infrared spectroscopy (fNIRS) is used to monitor hemodynamic changes via signal measurement. This study investigated the potential of using resting\u2010state fNIRS data through a convolutional neural network (CNN) to evaluate PD with orthostatic hypotension. The CNN demonstrated significant efficacy in analyzing fNIRS data, and it outperformed the other machine learning methods. The results indicate that judicious input data selection can enhance accuracy by over 85%, while including the correlation matrix as an input further improves the accuracy to more than 90%. This study underscores the promising role of CNN\u2010based fNIRS data analysis in the diagnosis and management of the PD. This approach enhances diagnostic accuracy, particularly in resting\u2010state conditions, and can reduce the discomfort and risks associated with current diagnostic methods, such as the head\u2010up tilt test.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202400138-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202400138","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T02:26:53Z","timestamp":1719887213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Convolutional neural networks can detect orthostatic hypotension in Parkinson's disease using resting\u2010state functional near\u2010infrared spectroscopy data"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-6787","authenticated-orcid":false,"given":"Seung Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Global Health Technology Research Center Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-3229","authenticated-orcid":false,"given":"Seung\u2010Ho","family":"Paik","sequence":"additional","affiliation":[{"name":"KLIEN Inc., Seoul Biohub  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-7589","authenticated-orcid":false,"suffix":"V","given":"Zephaniah","family":"Phillips","sequence":"additional","affiliation":[{"name":"Global Health Technology Research Center Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-9349","authenticated-orcid":false,"given":"Jung Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-7185","authenticated-orcid":false,"given":"Byung\u2010Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-5078","authenticated-orcid":false,"given":"Beop\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.031"},{"key":"e_1_2_8_5_1","first-page":"11","volume":"95","author":"Chen M. 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