{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:28:07Z","timestamp":1778783287279,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (MASLD) is one of the most prevalent chronic liver diseases worldwide. Thermal imaging combined with advanced image\u2010processing and machine learning analysis accurately classified disease status in a study on mice; this study aimed to develop this tool for humans. This prospective study included 46 patients who underwent liver biopsy. Liver thermal imaging was performed on the same day as liver biopsy. We developed an image\u2010processing algorithm that measured the relative spatial thermal variation across the skin covering the liver. The texture parameters obtained from the thermal images were input into the machine learning algorithm. Patients were diagnosed with MASLD and stratified according to nonalcoholic fatty liver disease activity score (NAS) and fibrosis stage using the METAVIR score. Twenty\u2010one of 46 patients were diagnosed with MASLD. Using thermal imaging followed by processing, detection accuracy for patients with NAS &gt;4 was 0.72.\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202400189-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.202400189","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T22:45:00Z","timestamp":1722984300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incorporating artificial intelligence in portable infrared thermal imaging for the diagnosis and staging of nonalcoholic fatty liver disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Yana","family":"Davidov","sequence":"first","affiliation":[{"name":"Liver Diseases Center, Sheba Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Y.","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica\u2010Inda","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Pathology Sheba Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya","family":"Likhter","sequence":"additional","affiliation":[{"name":"Liver Diseases Center, Sheba Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Hod","sequence":"additional","affiliation":[{"name":"Renal Transplant Center and Nephrology Department Sheba Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Pappo","sequence":"additional","affiliation":[{"name":"Department of Pathology Sheba Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Zimmer","sequence":"additional","affiliation":[{"name":"School of Medical Engineering Afeka Tel Aviv Academic College of Engineering  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehava","family":"Ovadia\u2010Blechman","sequence":"additional","affiliation":[{"name":"School of Medical Engineering Afeka Tel Aviv Academic College of Engineering  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Barlev","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Afeka Tel Aviv Academic College of Engineering  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orli","family":"Berman","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Afeka Tel Aviv Academic College of Engineering  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziv","family":"Ben Ari","sequence":"additional","affiliation":[{"name":"Liver Diseases Center, Sheba Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-3300","authenticated-orcid":false,"given":"Oshrit","family":"Hoffer","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Afeka Tel Aviv Academic College of Engineering  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000520"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30077-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31065"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24268"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","unstructured":"M.Yano H.Kumada M.Kage K.Ikeda K.Shimamatsu O.Inoue E.Hashimoto J. 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