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Using a novel side\u2010viewing handheld Raman probe, a total of 324 Raman spectra of four tissue types (i.e., thyroid, lymph node, PG, and lipid) commonly encountered during thyroidectomy were rapidly (&lt;\u20093\u2009s) acquired from 80 tissue sites (thyroid [<jats:italic>n<\/jats:italic>\u2009=\u200910], lymph node [<jats:italic>n<\/jats:italic>\u2009=\u200910], PG [<jats:italic>n<\/jats:italic>\u2009=\u200940], lipid [<jats:italic>n<\/jats:italic>\u2009=\u200920]) of 10 euthanized Wistar rats. Two partial least\u2010squares (PLS)\u2010discriminant analysis (DA) detection models were developed, differentiating the lipid and nonlipid (i.e., thyroid, lymph node, and PG) tissues with an accuracy of 100%, and PG, lymph node, and thyroid could be detected with an accuracy of 98.4%, 93.9%, and 95.4% respectively. This work demonstrates the feasibility of Raman spectroscopy technique for PG identification and protection during thyroidectomy at the molecular level.<\/jats:p>","DOI":"10.1002\/jbio.202400220","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:29:39Z","timestamp":1731392979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility Study of Label\u2010Free Raman Spectroscopy for\u00a0Parathyroid Gland Identification"],"prefix":"10.1002","volume":"18","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Optics and Photonics Beijing Institute of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Optics and Photonics Beijing Institute of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-7886","authenticated-orcid":false,"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Optics and Photonics Beijing Institute of Technology  Beijing China"},{"name":"Leibniz Institute of Photonic Technology Jena  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00027-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050596"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2020.1831913"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10297.RA"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26604"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24583"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3583571"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.04.072"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.06.047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.04.049"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3571-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.5.2.021220"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350615613450"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.04.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003700"},{"key":"e_1_2_8_19_1","first-page":"1329","article-title":"Optical Coherence Tomography Imaging During Thyroid and Parathyroid Surgery: A Novel System of Tissue Identification and Differentiation to Obviate Tissue Resection and Frozen Section","volume":"36","author":"Conti de Freitas L. 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