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This study aimed to examine the impact of PBM on reactive oxygen species (ROS), lipid peroxidation, and glutathione\u2010related antioxidant defense systems in rabbit eye tissues. A polychromatic light source with an intensity of 2.6\u2009J\/cm<jats:sup>2<\/jats:sup>\/min was used for PBM treatment in New Zealand White rabbits for 12\u2009min. The PBM group (<jats:italic>n<\/jats:italic>\u2009=\u20098) received treatments every 2\u2009days for a total of 12 sessions, whereas the control group (<jats:italic>n<\/jats:italic>\u2009=\u20098) did not undergo any PBM light exposure during the same period. The application of PBM significantly elevated ROS\u2010mediated glutathione levels, along with increased activities of glutathione peroxidase and reductase, particularly in corneal tissue (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). In conclusion, PBM treatment effectively enhances antioxidant defense mechanisms in the eye, particularly in corneal tissue, suggesting its potential as a therapeutic strategy for managing oxidative stress\u2010related ocular conditions.<\/jats:p>","DOI":"10.1002\/jbio.202400261","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T23:55:30Z","timestamp":1724975730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Photobiomodulation Application on Glutathione\u2010Related Antioxidant Defense System in Rabbit Eye Tissues"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-2802","authenticated-orcid":false,"given":"Mehmet","family":"Ozcan","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak 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