{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:36:07Z","timestamp":1778654167571,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Diabetes management often involves invasive blood glucose monitoring, which can be uncomfortable for patients. Non\u2010invasive techniques like multiple \u03bc\u2010spatially offset Raman spectroscopy (m\u03bcSORS) offer a promising alternative. To provide clinical data supporting m\u03bcSORS, we conducted a clinical trial with 198 participants to evaluate m\u03bcSORS for non\u2010invasive blood glucose measurement. Using Optical Coherence Tomography, we studied skin thickness and optical attenuation in 172 diabetic and 26 healthy subjects. Results showed thicker stratum corneum and stratum spinosum (SS) in diabetics. Epidermal thickness increased with age and body mass index (BMI), decreased with skin brightness, and varied minimally with gender. Optical attenuation in SS was lower in diabetics, decreased with increasing a*, and was minimally affected by gender and BMI but increased with age in the upper dermis. These findings support m\u03bcSORS for accurate non\u2010invasive glucose monitoring.<\/jats:p>","DOI":"10.1002\/jbio.202400267","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T03:24:51Z","timestamp":1729653891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Optical Attenuation and Skin Thickness in Type 2 Diabetes Mellitus Patients Using Optical Coherence\u00a0Tomography"],"prefix":"10.1002","volume":"17","author":[{"given":"Minghui","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Institute for Interventional Medical Devices, School of Health Science and Engineering, University of Shanghai for Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5121-1377","authenticated-orcid":false,"given":"Yue","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Institute for Interventional Medical Devices, School of Health Science and Engineering, University of Shanghai for Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingwei","family":"Su","sequence":"additional","affiliation":[{"name":"Photonic View Technology Co. Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Photonic View Technology Co. Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Photonic View Technology Co. Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-930X","authenticated-orcid":false,"given":"Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-7778","authenticated-orcid":false,"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"365","volume":"40","author":"Gao X.","year":"2023","journal-title":"Journal of Biomedical Engineering"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03091902.2022.2100496"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1366\/0003702053641450"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/254964"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-018-0107-0"},{"key":"e_1_2_9_7_1","first-page":"13","article-title":"Towards OCT\u2010Guided Endoscopic Laser Surgery\u2014A Review","volume":"13","author":"Gunalan A.","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72838-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19553"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.09.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/2\/006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118508"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497475"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12168277"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12209"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/1612-202X\/aa58c0"},{"key":"e_1_2_9_18_1","first-page":"8","article-title":"Quantitative and Qualitative Analysis of Healthy Skin by Anatomic Site Utilizing Optical Coherence Tomography and Attenuation Coefficient","volume":"11934","author":"May J.","year":"2022","journal-title":"Photonics in Dermatology and Plastic Surgery"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPHOT.2016.2520824"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2018.2873489"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/s130404041"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.000500"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3625247"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/1054-660X\/23\/4\/045602"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202400267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T03:43:07Z","timestamp":1738035787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202400267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/jbio.202400267"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202400267","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"2024-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400267"}}