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In this study, we developed an optical coherent elastography technique to assess the elasticity of the lens and lens capsule in the human eye. With age, the mean Young's modulus of the lens increased from 12.28\u2009\u00b1\u20090.87\u2009kPa to 18.59\u2009\u00b1\u20091.45\u2009kPa, and the lens capsule increased from 6.33\u2009\u00b1\u20090.36\u2009kPa to 13.33\u2009\u00b1\u20090.74\u2009kPa. The results showed that the Young's modulus of the lens capsule and lens increased with age, with the Young's modulus of the lens significantly higher than that of the lens capsule. This study reports the assessment of the elasticity of the human lens and lens capsule by the OCE technique, indicating that it may provide a potential clinical tool for advancing research on diseases affecting the lens.<\/jats:p>","DOI":"10.1002\/jbio.202400322","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T03:29:24Z","timestamp":1729222164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Quantitative Evaluation of Human Lens and Lens Capsule Elasticity by Optical Coherence Elastography Based on a Rayleigh Wave Model"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8090-4801","authenticated-orcid":false,"given":"Gang","family":"Shi","sequence":"first","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"},{"name":"Key Laboratory for Optoelectronic Information Perception 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