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This study introduces a thymoma classification technique that integrates hyperspectral imaging with deep learning. We initially capture pathological slice images of thymoma using a hyperspectral camera and delineate regions of interest to extract spectral data. This data undergoes reflectance calibration and noise reduction. Subsequently, we transform the spectral data into two\u2010dimensional images via the Gramian Angular Field (GAF) method. A variant residual network is then utilized to extract features and classify these images. Our results demonstrate that this model significantly enhances classification accuracy and efficiency, achieving an average accuracy of 95%. The method proves highly effective in automated thymoma diagnosis, optimizing data utilization, and feature representation learning.<\/jats:p>","DOI":"10.1002\/jbio.202400325","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:05:08Z","timestamp":1728000308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling Thymoma Typing Through Hyperspectral Imaging and Deep Learning"],"prefix":"10.1002","volume":"17","author":[{"given":"Qize","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChongXuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanHai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-4178","authenticated-orcid":false,"given":"YunZe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JinLin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WeiMing","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Qilu Hospital Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8169-0858","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Institute, School of Control Science and Engineering Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.01.012"},{"key":"e_1_2_12_3_1","volume-title":"Thoracic Tumours [Internet]","author":"Marx A.","year":"2021"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-020-01386-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13464"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248768"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25883"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09737766.2021.1958659"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12394-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2023.10.018"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2023.123412"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.10.019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.10.104003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103708"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300254"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2689178"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2018.12.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100142"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2017.00296"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/17.9.10"},{"issue":"4","key":"e_1_2_12_21_1","first-page":"287","article-title":"Wavelet Methods and Applications in Nonlinear Mechanics Problems","volume":"38","author":"Liu X. 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