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The tongue was subjected to photobiomodulation with red (71.4\u2009J\/cm<jats:sup>2<\/jats:sup>) and infrared laser (142.8\u2009J\/cm<jats:sup>2<\/jats:sup>) starting at week 0, 12, and 16. After 20\u2009weeks, tongues were removed for the following analyzes: histological assessment, immunohistochemical reactions (cyclin D1\/Ki\u201067\/TGF\u2010\u03b21), quantification of MPO, n\u2010AG, MDA, GSH, total proteins, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4\u2010NQO showed significant increase in the frequency of carcinoma (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and in the immunostaining for cyclin D1\/Ki\u201067\/TGF\u2010\u03b21 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005), along with increased levels of TNF\u2010 \u03b1, IL\u20101\u03b2, IL\u20106, MPO, n\u2010AG, MDA, and total proteins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), that were reduced by photobiomodulation with red and infrared lasers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Photobiomodulation reduces tumor development, accompanied by reduced inflammatory cells and content of cytokines and oxidative markers associated with carcinogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbio.202400390","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T07:09:20Z","timestamp":1737616160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photobiomodulation Exerts Anti\u2010Inflammatory and Antioxidant Effects Reducing the Development of Tumors Elicited by 4\u2010<scp>NQO<\/scp> in the Mice Tongue"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-0398","authenticated-orcid":false,"given":"Jos\u00e9 Ronildo Lins","family":"do Carmo Filho","sequence":"first","affiliation":[{"name":"Department of Dental Clinic, Division of Oral Pathology and Stomatology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00e1sly Costa","family":"Lima","sequence":"additional","affiliation":[{"name":"Superior Institute of Biomedical Sciences State University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Goberl\u00e2nio","family":"de Barros Silva","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Division of Oral Pathology and Stomatology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Negreiros Nunes","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Division of Oral Pathology and Stomatology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio Bitu","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Division of Oral Pathology and Stomatology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Sampaio","family":"Assreuy","sequence":"additional","affiliation":[{"name":"Superior Institute of Biomedical Sciences State University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Rog\u00e9rio Lima","family":"Mota","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic, Division of Oral Pathology and Stomatology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105451"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12190"},{"volume-title":"Head and Neck Tumours (WHO Classifcation of Tumours Series)","year":"2022","author":"WHO Classifcation of Tumours Editorial Board","key":"e_1_2_10_4_1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071949"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042010000600007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-72992003000400018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3153-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22419"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500292"},{"key":"e_1_2_10_11_1","first-page":"1385","article-title":"Low\u2010Level Laser Therapy Promotes Proliferation and Invasion of Oral Squamous Cell Carcinoma Cells","volume":"29","author":"Gomes Henriques A. 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