{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:02Z","timestamp":1753869302234,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Local therapeutic action and targeted drug release are promising approaches compared to traditional systemic drug administration. This is especially relevant for nitric oxide (NO), as its effects change dramatically depending on concentration and cellular context. Materials capable of releasing NO in deep tissues in a controlled manner might open new therapeutic opportunities. Light\u2010sensitive NO donors represent a fascinating class of compounds with significant potential for precise and controlled NO release. However, most of them are sensitive to visible light, with only a few examples absorbing in a near\u2010infrared therapeutic window. Here, we present the proof\u2010of\u2010concept of soft implants consisting of the photon upconverting core and the outer shell loaded with visible\u2010light triggered NO donor. The separation into two compartments results in efficient energy harvesting by the dye and effective NO release under 980\u2009nm infrared irradiation. Such implants could be used in smart therapies implying well\u2010controlled and localized NO release.<\/jats:p>","DOI":"10.1002\/jbio.202400455","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T04:57:31Z","timestamp":1735189051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prototype of Implant for Nitric Oxide Release Controlled by\u00a0Infrared Radiation in Therapeutic Window"],"prefix":"10.1002","volume":"18","author":[{"given":"Natalia A.","family":"Virts","sequence":"first","affiliation":[{"name":"Novosibirsk State University  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana Yu.","family":"Karogodina","sequence":"additional","affiliation":[{"name":"Novosibirsk State University  Novosibirsk Russia"},{"name":"N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail A.","family":"Panfilov","sequence":"additional","affiliation":[{"name":"N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey Yu.","family":"Vorob'ev","sequence":"additional","affiliation":[{"name":"Novosibirsk State University  Novosibirsk Russia"},{"name":"N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-7757","authenticated-orcid":false,"given":"Alexander E.","family":"Moskalensky","sequence":"additional","affiliation":[{"name":"Novosibirsk State University  Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja413063e"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.11.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895\u2010020\u201002643\u20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.15\u2010100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.001135"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652412798376099"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2607"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20092"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106050"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3c01421"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110531"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8PP00272J"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.027"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2022.118837"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv\u20102022\u2010m2z57\u2010v2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.326"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b05514"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2023.101445"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207250"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304994"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.201700281"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043805\u2010y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010022\u201000871\u2010z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15040092"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201050656\u20106"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162731"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12071520"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S82199"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.12.056"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00586"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.048"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202400455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T17:56:49Z","timestamp":1741456609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202400455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,25]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jbio.202400455"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202400455","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"type":"print","value":"1864-063X"},{"type":"electronic","value":"1864-0648"}],"subject":[],"published":{"date-parts":[[2024,12,25]]},"assertion":[{"value":"2024-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400455"}}