{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:59Z","timestamp":1753869299154,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019470","name":"Lazio Innova","doi-asserted-by":"publisher","award":["A0613.2023.077528","CUP F89J23001100007"],"award-info":[{"award-number":["A0613.2023.077528","CUP F89J23001100007"]}],"id":[{"id":"10.13039\/100019470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study investigated the effect of a theranostic\u2010guided UV\u2010A light corneal photo\u2010reshaping technique on corneal elevation and wavefront aberration (WA) in human donor eyes. A specialized platform, combining UV\u2010A light with corneal iontophoresis for controlled, patterned, riboflavin delivery, was used for both distribution assessment and concentration\u2010driven photopolymerization of corneal proteins. In all cases, a consistent riboflavin concentration gradient, with lower levels in the central prepupillary zone, was recorded. Corneal topography and WA measurements showed significant corneal steepening and smooth wavefront shaping, respectively, with a delay in the central 2.0\u2009mm of the WA and advancement in the surrounding zone, as well as a 50% reduction in corneal spherical aberration over a 5.0\u2009mm pupil size. Notably, the corneal optical quality, measured via modulation transfer function (MTF), remained stable. This incision\u2010free approach demonstrated the potential to extend focal range without compromising distance vision, presenting a new solution for presbyopia correction.<\/jats:p>","DOI":"10.1002\/jbio.202400462","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:40:29Z","timestamp":1734050429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Theranostic\u2010Guided <scp>UV\u2010A<\/scp> Light Corneal Wavefront Photo\u2010Reshaping for Presbyopia Correction: A\u00a0Preclinical Study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-7102","authenticated-orcid":false,"given":"Marco","family":"Lombardo","sequence":"first","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"Vision Engineering Italy srl  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-1338","authenticated-orcid":false,"given":"Giuseppe Massimo","family":"Bernava","sequence":"additional","affiliation":[{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Serrao","sequence":"additional","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"Vision Engineering Italy srl  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-967X","authenticated-orcid":false,"given":"Giuseppe","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Studio Italiano di Oftalmologia  Rome Italy"},{"name":"CNR\u2010IPCF, Istituto per i Processi Chimico\u2010Fisici  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2024.102157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.04.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108477"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180726-02"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_32_20"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-017-0075-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S375577"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000001270"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.124080"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"312","article-title":"Complications of Small Aperture Intracorneal Inlays: A Literature Review","volume":"13","author":"S\u00e1nchez\u2010Gonz\u00e1lez M. C.","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108474"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000774"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3281df2cf0"},{"issue":"1","key":"e_1_2_10_15_1","article-title":"Trifocal Intraocular Lenses Versus Bifocal Intraocular Lenses After Cataract Extraction Among Participants With Presbyopia","volume":"1","author":"Zamora\u2010de La Cruz D.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-022-01002-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-196606010-00004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9385"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"A Critical Review on the Kinetics, Efficacy, Safety, Nonlinear Law and Optimal Protocols of Corneal Crosslinking","volume":"3","author":"Lin J.\u2010T.","year":"2018","journal-title":"Journal of Ophthalmology & Visual Neuroscience"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23414"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000001163"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202200218"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.06.012"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202400068"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.12.013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.12.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.06.011"},{"key":"e_1_2_10_28_1","first-page":"253","article-title":"Anterior\u2010Posterior Strain Variation in Normally Hydrated and Swollen Rabbit Cornea","volume":"39","author":"Hennighausen H.","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73521-4"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-199511000-00005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.09.026"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/4.4.9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2011.05.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.24.000588"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(88)80063-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.7.001877"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1995.tb00006.x"},{"key":"e_1_2_10_38_1","first-page":"2962","article-title":"Interlamellar Cohesive Strength in the Vertical Meridian of Human Eye Bank Corneas","volume":"34","author":"Smolek M. K.","year":"1993","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175002"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8059"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12498"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S400083"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000712"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000978"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144758"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202400462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:04:40Z","timestamp":1739232280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202400462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jbio.202400462"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202400462","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"type":"print","value":"1864-063X"},{"type":"electronic","value":"1864-0648"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400462"}}