{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:59:00Z","timestamp":1773014340386,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["21\u201018578S"],"award-info":[{"award-number":["21\u201018578S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This paper describes a compact video\u2010ophthalmoscope (VO) designed for capturing retinal video sequences of the optic nerve head (ONH) under flicker light stimulation. The device uses an OLED display and a fiber optic\u2010coupled LED light source, enabling high\u2010frame\u2010rate video at low illumination intensity (12\u2009\u03bcW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ). Retinal responses were recorded in 10 healthy subjects during flicker light exposure with a pupil irradiance of 2\u2009\u03bcW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . Following 20\u2009s of stimulation, all subjects displayed changes in retinal reflectance and pulsation attenuation, linked to blood flow and volume variations. These findings suggest that increased blood volume leads to decreased retinal reflectance. Temporal analysis confirmed the ability\u00a0to\u00a0capture\u00a0flicker\u2010induced retinal reflectance changes, indicating its potential for spatial and temporal analysis. Overall, this device offers a portable approach for investigating dynamic retinal responses to light stimuli, which can aid the diagnosis of retinal diseases like diabetic retinopathy, glaucoma, or neurodegenerative diseases affecting retinal blood circulation.\n                  <\/jats:p>","DOI":"10.1002\/jbio.202400494","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:16:48Z","timestamp":1741681008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compact Monocular Video\u2010Ophthalmoscope to Measure Retinal Reflectance Changes to Flicker Light Stimuli"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0469-6397","authenticated-orcid":false,"given":"Radim","family":"Kolar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Vicar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Chmelik","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Jakubicek","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Odstrcilik","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Nohel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication Brno University of Technology  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Skorkovska","sequence":"additional","affiliation":[{"name":"Deparment of Ophthalmology and Optometry St. Ann University Hospital  Brno Czech Republic"},{"name":"Department of Ophthalmology and Optometry Masaryk University  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf P.","family":"Tornow","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander\u2010University Erlangen\u2013N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.08.069"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optlaseng.2004.04.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201057263\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00452"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0038\u201012.2012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.9.002351"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.004942"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.9.006237"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202200094"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.441451"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2003.11.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.001852"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207525"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00495.2020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/ECBO.2015.954006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.486052"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010020\u201004934\u2010y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.3039917"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003441\u20106"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1125154"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.07.002"},{"issue":"8","key":"e_1_2_9_23_1","first-page":"2721","article-title":"Influence 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