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While noninvasive transcutaneous bilirubinometers (TcB) are available, that often lack accuracy due to interference from other biological chromophores. This study aims to improve bilirubin assessment by developing a noninvasive system that uses diffuse reflectance spectroscopy and a novel algorithm accounting for chromophores like melanin and hemoglobin. Focusing on the sternum as the measurement site, spectra are collected from 285 newborns. Using the proposed algorithm, the bilirubin concentration is calculated at 450, 460, and 470\u2009nm. Compared to TSB levels, the proposed method demonstrated strong accuracy with an average bias of \u22120.10\u2009mg\/dL and narrower limits of agreement of 4.85 mg\/dL at 470\u2009nm.<\/jats:p>","DOI":"10.1002\/jbio.202400505","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:45:12Z","timestamp":1740105912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development and Validation of a Noninvasive Diffuse Reflectance Spectroscopic Method for Bilirubin Estimation in Neonates"],"prefix":"10.1002","volume":"18","author":[{"given":"Chitra","family":"R","sequence":"first","affiliation":[{"name":"Department of Electronics and Communication Engineering SRM Institute of Science and Technology, Kattankulathur Campus  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-622X","authenticated-orcid":false,"given":"Shanthi","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering SRM Institute of Science and Technology, Kattankulathur Campus  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Neonatology SRM Medical College Hospital and Research Centre, Kattankulathur Campus  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SRM Medical College Hospital and Research Centre, Kattankulathur Campus  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.15\u201011\u2010422"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(58)90366\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065\u20103101(24)00052\u20105"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2017.78.12.699"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010058859"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1969.02100040456007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1990.11747405"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018\u20102039"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(60)92902\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151355"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1292678"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101040549"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.65.2.195"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/ajcprx1e3nwcxhmz"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.484471"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u201012\u201070"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.2004.tb02635.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010020\u201001118\u20106"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2019.01.019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe3793"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","unstructured":"I.Nishidate W. 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