{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:47:35Z","timestamp":1768816055697,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) often share similar features, leading to frequent misdiagnoses. Hyperspectral imaging (HSI) offers detailed spatial and spectral insights, promising improved tumor detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to discern HT and PTC spectral characteristics using HSI and evaluate deep learning models for pathologic diagnostic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hyperspectral data from HT and PTC samples were processed using second\u2010order derivatives and Savitzky\u2013Golay smoothing. The adaptive spectral feature selection network model classified spectral data from various wavelengths to assess performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PTC showed unique spectral features in the 400\u2013500\u2009nm range with higher peak intensities at lower wavelengths than HT. The model achieved 88.36% accuracy, highlighting the importance of low\u2010wavelength data in differentiating PTC from HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The model effectively identifies spectral differences between HT and PTC, offering a novel approach for precise thyroid disease diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbio.202500123","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:02Z","timestamp":1747185062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of Hyperspectral Imaging and Machine Learning for Differential Diagnosis of Hashimoto's Thyroiditis and Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9776-5025","authenticated-orcid":false,"given":"Yue","family":"Xiaoqing","sequence":"first","affiliation":[{"name":"College of Integrative Medicine Nanjing University of Traditional Chinese Medicine  Nanjing China"},{"name":"Department of Traditional Chinese Medicine Yucheng People's Hospital  Dezhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Danfeng","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Nanjing University of Traditional Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hongmin","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Yucheng People's Hospital  Dezhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhengyuan","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Nanjing University of Traditional Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lv","family":"Haiyue","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, School of Acupuncture and Tuina  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Tianyi","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Nanjing University of Traditional Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Huanjun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabology The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2978"},{"key":"e_1_2_8_3_1","article-title":"Multiplex Imaging Analysis in Pathology: A Comprehensive Review on Analytical Approaches and Digital Toolkits","author":"Omar M.","year":"2024","journal-title":"arXiv"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28054"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2013.838678"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2019.12.53"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.32768\/abc.202074189-201"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300276"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061662"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174292"},{"key":"e_1_2_8_11_1","article-title":"Thyroid Carcinoma Detection on Whole Histologic Slides Using Hyperspectral Imaging and Deep Learning","volume":"12039","author":"Tran M. 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