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The distinct feature of the suggested biosensor is the design of a nano\u2010cavity with two different rod radii. The designed biosensor is intended for identifying diabetic blood samples, malaria, and chikungunya virus. The proposed biosensor achieves a high quality factor (QF) of 8080, a high sensitivity (S) of 1108\u2009nm\/RIU with a low detection limit (DL) of 9.02\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>\u2009RIU, towards breast cancer analysis. The QF, S, and DL of the biosensor for the diabetic blood sample are 6963, 1087\u2009nm\/RIU, and 1.01\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>\u2009RIU respectively. The highest QF and sensitivity of the biosensor are 8561 and 1121.6\u2009nm\/RIU respectively, towards malarial detection. A high QF of 9129.4 and a high sensitivity of 1166.9 is achieved for infected plasma towards chikungunya virus detection.<\/jats:p>","DOI":"10.1002\/jbio.202500130","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:30:02Z","timestamp":1748327402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design and Analysis of a Novel Nanoscale 2D Photonic Crystal Structure for Enhanced Multi\u2010Disorder Biosensing"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-4389","authenticated-orcid":false,"given":"K.","family":"Bhuvaneshwari","sequence":"first","affiliation":[{"name":"Department of Electronics and Communication Engineering Sri Venkateswara College of Engineering  Kanchipuram Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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