{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:42:19Z","timestamp":1783035739471,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">\n<jats:italic>Helicobacter pylori<\/jats:italic>\n<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">\n<jats:italic>H. pylori<\/jats:italic>\n<\/jats:styled-content>) is a bacterium that infects the stomach and can lead to conditions like peptic ulcers, chronic gastric inflammation, and stomach cancer. A key feature of <jats:styled-content style=\"fixed-case\">\n<jats:italic>H. pylori<\/jats:italic>\n<\/jats:styled-content> is urease, an enzyme that breaks down urea into ammonium carbonate. Various methods exist for diagnosing <jats:styled-content style=\"fixed-case\">\n<jats:italic>H. pylori<\/jats:italic>\n<\/jats:styled-content> infections, including breath tests. This study expands on previous research that focused on ammonia detection by introducing a novel approach using photoacoustic spectroscopy to measure ethylene and carbon dioxide levels in the breath of infected individuals. Our results show significant differences in gas concentrations between <jats:styled-content style=\"fixed-case\">\n<jats:italic>H. pylori<\/jats:italic>\n<\/jats:styled-content>\u2010infected individuals and healthy controls. Ethylene concentrations were 113.64% higher, and carbon dioxide levels were 433.47% higher in infected participants, suggesting that both gases may serve as biomarkers for <jats:styled-content style=\"fixed-case\">\n<jats:italic>H. pylori<\/jats:italic>\n<\/jats:styled-content> detection.<\/jats:p>","DOI":"10.1002\/jbio.202500140","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:51:19Z","timestamp":1747644679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of <scp><i>Helicobacter pylori<\/i><\/scp> Through <scp>C<sub>2<\/sub>H<sub>4<\/sub><\/scp> and <scp>CO<sub>2<\/sub><\/scp> Breath Markers Using Photoacoustic Spectroscopy"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-6956","authenticated-orcid":false,"given":"Cristina","family":"Popa","sequence":"first","affiliation":[{"name":"Laser Department National Institute for Laser, Plasma and Radiation Physics  Magurele Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioara","family":"Petrus","sequence":"additional","affiliation":[{"name":"Laser Department National Institute for Laser, Plasma and Radiation Physics  Magurele Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Bratu","sequence":"additional","affiliation":[{"name":"Laser Department National Institute for Laser, Plasma and Radiation Physics  Magurele Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.09.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202400074"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00172-07"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05930-9"},{"key":"e_1_2_9_6_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","author":"International Agency for Research on Cancer (IARC)","year":"1999"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574\u2010199911000\u201000006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.917184"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302532"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1536383X.2023.2179038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/1536383X.2023.2193399"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020191"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00037028231208712"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00340\u2010008\u20103127\u2010y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-0891(89)90129-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios10060055"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"S.SahaandS.Saha \u201cNon\u2010Invasive Monitoring of Human Health by Exhaled Breath Analysis: A Comprehensive Review \u201d167 no.3(2020):037562.","DOI":"10.1149\/1945-7111\/ab67a6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5772\/2496"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5772\/2496"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2018.02.030"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.5.057006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00340\u2010011\u20104716\u20108"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071728"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2010.05.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113618"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20101302\u20103_2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012080.pub2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1460"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.04.023"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7348.1263"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i17.2302"},{"issue":"5","key":"e_1_2_9_32_1","first-page":"669","article-title":"Non\u2010Invasive Techniques for the Diagnosis of Helicobacter pylori Infection","volume":"17","author":"Gatta L.","year":"2003","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071558"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840909"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"81","article-title":"Non\u2010Invasive Methods for Detecting Helicobacter pylori Infection","volume":"10","author":"Vaira D.","year":"2005","journal-title":"Helicobacter"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.4c02785"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10936"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202500140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:53:20Z","timestamp":1752623600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202500140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jbio.202500140"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202500140","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500140"}}