{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:32:13Z","timestamp":1787167933254,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study presents a novel diagnostic approach that integrates hyperspectral imaging (HSI) with deep learning to discriminate among dermatitis, actinic keratosis (AK), and seborrheic keratosis (SK). We evaluated 60 intraoperative clinical specimens and achieved 93% accuracy, 91% sensitivity, and 95% specificity in three\u2010class classification. A Savitzky\u2013Golay filter was applied to the raw spectra to enhance the signal\u2010to\u2010noise ratio and data fidelity, while first\u2010derivative spectral analysis enabled the model to capture subtle biochemical and morphological differences among lesions. Our results demonstrate that the combined HSI\u2013deep\u2010learning framework can accelerate dermatologic diagnosis and reduce error rates. This methodology not only provides a robust tool for clinical decision support in dermatology but also holds promise for wider adoption across medical imaging workflows. Future work will focus on scalability, cost\u2013benefit optimization, and seamless integration with existing diagnostic platforms.<\/jats:p>","DOI":"10.1002\/jbio.202500182","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:25:06Z","timestamp":1749752706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhancing the Accuracy of Skin Lesion Diagnosis Using Hyperspectral Imaging and Deep Learning"],"prefix":"10.1002","volume":"18","author":[{"given":"Huiwen","family":"Zheng","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Sino\u2010Finland Joint AI Laboratory for Child Health of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Ren","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Yu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenying","family":"Cai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xia","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Qi","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Sino\u2010Finland Joint AI Laboratory for Child Health of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Sino\u2010Finland Joint AI Laboratory for Child Health of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-9345","authenticated-orcid":false,"given":"Chen","family":"Shen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Sino\u2010Finland Joint AI Laboratory for Child Health of Zhejiang Province  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2021-0257"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19559"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"265","article-title":"Seborrheic Keratosis","volume":"21","author":"Barthelmann S.","year":"2023","journal-title":"JDDG: Journal of the German Society of Dermatology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.03.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2021.3052044"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00162-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.153"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10619-021-07360-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICIIP61524.2023.10537681"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101915"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213838"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11042-023-14697-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-021-00041-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.3024923"},{"issue":"10","key":"e_1_2_10_16_1","first-page":"100901\u20131","article-title":"Review of Spectral Imaging Technology in Biomedical Engineering: Achievements and Challenges","volume":"18","author":"Zhang H.","year":"2013","journal-title":"Journal of Biomedical Optics"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2023.03.149"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031134"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174292"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.27.10.106007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2646999"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21113738"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00037028231154278"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1364\/OSAC.410807"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202500182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:53:14Z","timestamp":1752623594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202500182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jbio.202500182"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202500182","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500182"}}