{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:44:09Z","timestamp":1790621049221,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated changes in the pulse waveform recorded by photoplethysmography (PPG) during a local heating test in patients with diabetes. The following groups of subjects were studied: healthy individuals (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915), patients with Type 2 diabetes accompanied by diabetic retinopathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), patients with Type 2 diabetes and diabetic foot syndrome (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916). Measurements were taken from the big toes of both limbs while the skin was heated from 32\u00b0C to 42\u00b0C. We found statistically significant changes in PPG waveform after heating between all three groups. The main change is that the dicrotic notch becomes more pronounced during the heating period. This effect is strongest in Group 1, slightly less pronounced in Group 2, and practically absent in Group 3. Thus, monitoring of the PPG waveform during the heating test may be an effective means of assessing microvascular lesions in diabetes.\n                  <\/jats:p>","DOI":"10.1002\/jbio.202500190","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T11:44:22Z","timestamp":1753962262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes\u2010Associated Changes in the Toe Photoplethysmogram During Local Heating Test"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-0144","authenticated-orcid":false,"given":"Denis","family":"Lapitan","sequence":"first","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"Xing","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, School of Biomedical Engineering (Suzhou) University of Science and Technology of China  Suzhou China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Glazkov","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia","family":"Krasulina","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Glazkova","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Britvin","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Zagarov","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Larkov","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Rogatkin","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute (\u201cMONIKI\u201d)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02317\u20101"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14242830"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.14341\/DM8014\u20106906"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202000203"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics10040442"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/28\/3\/R01"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340312801215782"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135659"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22134890"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/35\/10\/2027"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/PERCOMW.2017.7917526"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2018.09.007"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2009.11.004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.18786\/2072\u20100505\u20102016\u201044\u20102\u2010249\u2010259"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4172\/0974\u20108369.1000361"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010016\u20100487\u20101"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.05.005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1619"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.01.001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010023\u201003506\u20104"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/36\/9\/1801"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1753\u20104631\u20105\u20101"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106579\/ab755d"},{"key":"e_1_2_12_25_1","first-page":"71","article-title":"Evaluation of the Age\u2010Related Changes of Elasticity of Peripheral Vascular Walls by Photoplethysmography","volume":"87","author":"Lapitan D. G.","year":"2020","journal-title":"Meditsinskaia Fizika"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10916\u2010018\u20100901\u20101"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1109\/IECBES.2018.8626681"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20956"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/informatics11030051"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549\u20108719.2009.00018.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH\u201015107"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.439893"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.202500190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:09:15Z","timestamp":1763338155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.202500190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jbio.202500190"],"URL":"https:\/\/doi.org\/10.1002\/jbio.202500190","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500190"}}