{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:42:04Z","timestamp":1791362524761,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH319"],"award-info":[{"award-number":["ZR2022QH319"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015508","name":"Shandong Academy of Medical Sciences","doi-asserted-by":"publisher","award":["202201\u2010085"],"award-info":[{"award-number":["202201\u2010085"]}],"id":[{"id":"10.13039\/501100015508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QF092"],"award-info":[{"award-number":["ZR2022QF092"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Papillary thyroid carcinoma (PTC) and nodular goiter with papillary hyperplasia (NGPH) share similar histological features, complicating both preoperative and intraoperative diagnoses. We assessed hyperspectral imaging (HSI) combined with deep learning to differentiate PTC from NGPH. Forty\u2010three paraffin\u2010embedded PTC and 39 NGPH samples were imaged across 400\u20131000\u2009nm, with reflectance calibration and Savitzky\u2013Golay smoothing applied. Extracted spectral features were input into a one\u2010dimensional convolutional neural network with a self\u2010attention mechanism. HSI demonstrated sensitivity above 90% in the 500\u2013600\u2009nm and near\u2010infrared regions for distinguishing PTC and NGPH. The model achieved an area under the ROC curve of 0.8635 and pixel\u2010level classification accuracy of 87.07%, with both sensitivity and specificity at 87%. Spectral feature depth correlated significantly with histopathological parameters. These findings indicate that HSI combined with deep learning can accurately capture spectral differences between PTC and NGPH, supporting its potential for rapid intraoperative guidance and noninvasive preoperative screening.<\/jats:p>","DOI":"10.1002\/jbio.202500200","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T21:39:30Z","timestamp":1751492370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Diagnosis of Papillary Thyroid Carcinoma and Nodular Goiter With Papillary Hyperplasia Using Hyperspectral Imaging Technology"],"prefix":"10.1002","volume":"18","author":[{"given":"Baohua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology Zibo Central Hospital  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease 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